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ArticleBMJ open2024

Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS-protocol for a Delphi study.

Prashant Nasa, Lieuwe D Bos, Elisa Estenssoro, Frank Mp van Haren, Ary Serpa Neto, Patricia Rm Rocco, Arthur S Slutsky, Marcus J Schultz

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06159465 (Consensus Statements on the Utility of Defining ARDS and the Utility of Past and Current Definitions of ARDS--Protocol for a Delphi Study), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06159465 completednot on this map

Consensus Statements on the Utility of Defining ARDS and the Utility of Past and Current Definitions of ARDS--Protocol for a Delphi Study

TypeobservationalSponsorNMC Specialty HospitalRan2023 to 2024Enrolled40ConditionsRespiratory Distress Syndrome, Adult, Hypoxemic Respiratory Failure, Respiratory Failure, Phenotypic Abnormality
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. From the Oracle of Delphi to Intensive Care Unit Guidelines: Consensus Building Using the Delphi Method.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  4. Review
  5. Defining the Acute Respiratory Distress Syndrome - Are You a Splitter or a Lumper? The Choice Matters more than You Think.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prashant NasaDepartment of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands dr.prashantnasa@hotmail.com.ORCID 0000-0003-1948-4060
Lieuwe D BosDepartment of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands.
Elisa EstenssoroFacultad de Ciencias Médicas, Universidad Nacional de la Plata, La Plata, Argentina.
Frank Mp van HarenCollege of Health and Medicine, Australian National University, Canberra, ACT, Australia.ORCID 0000-0001-8037-4229
Ary Serpa NetoDepartment of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands.
Patricia Rm RoccoLaboratory of Pulmonary Investigations, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Arthur S SlutskyInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Marcus J SchultzDepartment of Intensive Care, Amsterdam UMC, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute respiratory distress syndrome (ARDS), marked by acute hypoxemia and bilateral pulmonary infiltrates, has been defined in multiple ways since its first description. This Delphi study aims to collect global opinions on the conceptual framework of ARDS, assess the usefulness of components within current and past definitions and investigate the role of subphenotyping. The varied expertise of the panel will provide valuable insights for refining future ARDS definitions and improving clinical management.

methodsA diverse panel of 35-40 experts will be selected based on predefined criteria. Multiple choice questions (MCQs) or 7-point Likert-scale statements will be used in the iterative Delphi rounds to achieve consensus on key aspects related to the utility of definitions and subphenotyping. The Delphi rounds will be continued until a stable agreement or disagreement is achieved for all statements. ANALYSIS: Consensus will be considered as reached when a choice in MCQs or Likert-scale statement achieved ≥80% of votes for agreement or disagreement. The stability will be checked by non-parametric χ ETHICS AND DISSEMINATION: The study will be conducted in full concordance with the principles of the Declaration of Helsinki and will be reported according to CREDES guidance. This study has been granted an ethical approval waiver by the NMC Healthcare Regional Research Ethics Committee, Dubai (NMCHC/CR/DXB/REC/APP/002), owing to the nature of the research. Informed consent will be obtained from all panellists before the start of the Delphi process. The study will be published in a peer-review journal with the authorship agreed as per TRIAL REGISTRATION NUMBER: NCT06159465.

Indexed as

Delphi TechniqueRespiratory Distress SyndromeConsensus Statements as TopicHumansResearch DesignAdult intensive & critical careRespiratory Distress SyndromeRespiratory Therapy

Identifiers

PMID38670604
PMCPMC11057280

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.