Evidence map›Paper›PMID 38670600›Full record

SynthesisBMJ open2024

HIV pre-exposure prophylaxis uptake, retention and adherence among female sex workers in sub-Saharan Africa: a systematic review.

Ruth Mpirirwe, Ivan Segawa, Kevin Ouma Ojiambo, Onesmus Kamacooko, Joanita Nangendo, Fred C Semitala, Peter Kyambadde, Joan N Kalyango, Agnes Kiragga, Charles Karamagi and 3 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ruth MpirirweClinical Epidemiology, Makerere University College of Health Sciences, Kampala, Uganda ruthmpirirwe@gmail.com.ORCID 0009-0009-7925-4807
Ivan SegawaClinical Epidemiology, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0002-4535-1694
Kevin Ouma OjiamboClinical Epidemiology Unit, Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0003-4257-3926
Onesmus KamacookoCollege of Health Sciences, Makerere University, Kampala, Uganda.
Joanita NangendoMakerere University, Kampala, Uganda.
Fred C SemitalaInfectious Diseases Research Collaboration, Kampala, Uganda.
Peter KyambaddeRepublic of Uganda Ministry of Health, Kampala, Uganda.
Joan N KalyangoClinical Epidemiology, Makerere University College of Health Sciences, Kampala, Uganda.
Agnes KiraggaInfectious Diseases Institute, Makerere University, Kampala, Uganda.
Charles KaramagiClinical Epidemiology Unit, Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Anne KatahoireCollege of Health Sciences, Makerere University, Kampala, Uganda.
Moses KamyaMakerere University, Kampala, Uganda.
Andrew MujugiraMakerere University, Kampala, Uganda.

Funding

Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in UgandaD43TW011304 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI Carol Suzanne Camlin, MOSES Robert KAMYA · 2019 to 2026
$2.2M
FIC NIH HHS D43 TW011304
6 · The paper itself

Abstract

objectiveTo evaluate oral pre-exposure prophylaxis (PrEP) uptake, retention and adherence among female sex workers (FSWs) receiving care through community and facility delivery models in sub-Saharan Africa (SSA).

designSystematic review and meta-analysis. DATA SOURCES: We searched online databases (PubMed, MEDLINE, SCOPUS, EMBASE, Google Scholar, Cochrane Database of Systematic Reviews and Web of Science) between January 2012 and 3 April 2022. ELIGIBILITY CRITERIA FOR STUDIES: Randomised controlled trials, cohort studies, cross-sectional studies and quasi-experimental studies with PrEP uptake, adherence and retention outcomes among FSWs in SSA. DATA EXTRACTION AND SYNTHESIS: Seven coders extracted data. The framework of the Cochrane Consumers and Communication Review Group guided data synthesis. The Risk of Bias In Non-Randomized Studies of Interventions tool was used to evaluate the risk of bias. Meta-analysis was conducted using a random-effects model. A narrative synthesis was performed to analyse the primary outcomes of PrEP uptake, adherence and retention.

resultsOf 8538 records evaluated, 23 studies with 40 669 FSWs were included in this analysis. The pooled proportion of FSWs initiating PrEP was 70% (95% CI: 56% to 85%) in studies that reported on facility-based models and 49% (95% CI: 10% to 87%) in community-based models. At 6 months, the pooled proportion of FSWs retained was 66% (95% CI: 15% to 100%) for facility-based models and 83% (95% CI: 75% to 91%) for community-based models. Factors associated with increased PrEP uptake were visiting a sex worker programme (adjusted OR (aOR) 2.92; 95% CI: 1.91 to 4.46), having ≥10 clients per day (aOR 1.71; 95% CI: 1.06 to 2.76) and lack of access to free healthcare in government-run health clinics (relative risk: 1.16; 95% CI: 1.06 to 1.26).

conclusionsA hybrid approach incorporating both facility-based strategies for increasing uptake and community-based strategies for improving retention and adherence may effectively improve PrEP coverage among FSWs. PROSPERO REGISTRATION NUMBER: CRD42020219363.

Indexed as

Drug MonitoringHIV InfectionsPre-Exposure ProphylaxisSex WorkersAfrica South of the SaharaAnti-HIV AgentsFemaleHumansAnti-HIV Agentsbehaviorepidemiologyhealth policyhealth servicesHIV & AIDSsystematic review

Identifiers

PMID38670600
PMCPMC11057315

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.