Evidence map›Paper›PMID 38670599›Full record

ArticleBMJ open2024

Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV).

Stefan Hagel, Nicole Brillinger, Sebastian Decker, Maria Deja, Christian Ertmer, Sandra Fiedler, Philipp Franken, Markus Heim, Markus A Weigand, Alexander Zarbock and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06134492 (Effect of Acyclovir Therapy on the Outcome of Ventilated Patients With Lower Respiratory Tract Infection and Detection of Herpes Simplex Virus in Bronchoalveolar Lavage), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06134492 phase3recruitingnot on this map

Effect of Acyclovir Therapy on the Outcome of Ventilated Patients With Lower Respiratory Tract Infection and Detection of Herpes Simplex Virus in Bronchoalveolar Lavage

TypeinterventionalSponsorJena University HospitalRan2024 to 2026Enrolled616ConditionsPneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes SimplexArmsAcyclovir
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Stefan HagelFriedrich Schiller University Jena, Jena, Germany stefan.hagel@med.uni-jena.de.ORCID 0000-0003-2999-6131
Nicole BrillingerCenter for Clinical Studies, Universitatsklinikum Jena, Jena, Thüringen, Germany.
Sebastian DeckerDepartment of Anesthesiology, Heidelberg University, Heidelberg, Germany.
Maria DejaDepartment of Anesthesiology and Intensive Care Medicine, University of Schleswig-Holstein, Lübeck, Germany.
Christian ErtmerUniversity Hospital of Muenster, Münster, Germany.
Sandra FiedlerJena University Hospital, Jena, Thüringen, Germany.
Philipp FrankenFriedrich Schiller University Jena, Jena, Germany.
Markus HeimKlinikum rechts der Isar der Technischen Universitat Munchen, Munchen, Germany.
Markus A WeigandDepartment of Anaesthesia, UniversitatsKlinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany.
Alexander ZarbockUniversität Münster, Münster, Germany.ORCID 0000-0002-2124-1714
Mathias W PletzCenter for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.ORCID 0000-0001-8157-2753
SepNet Critical Care Trials Group
Friedrich Schiller University Jena · DEHeidelberg University · DEJena University Hospital · DECenter for Clinical Studies · USTUM Klinikum · DEUniversity Hospital Münster · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHerpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and is associated with a worse outcome. The aim of this study is to determine whether antiviral therapy in HSV-positive patients improves outcome. METHODS AND ANALYSIS: Prospective, multicentre, open-label, randomised, controlled trial in parallel-group design. Adult, mechanically ventilated patients with pneumonia and HSV type 1 detected in bronchoalveolar lavage (≥10 ETHICS AND DISSEMINATION: The trial was approved by the responsible ethics committee and by Germany's Federal Institute for Drugs and Medical Devices. The clinical trial application was TRIAL REGISTRATION NUMBER: NCT06134492.

Indexed as

AcyclovirAntiviral AgentsRespiration, ArtificialAdultBronchoalveolar LavageBronchoalveolar Lavage FluidFemaleHerpes SimplexHerpesvirus 1, HumanHumansIntensive Care UnitsMaleMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicRespiratory Tract InfectionsAcyclovirAntiviral AgentsAdult intensive & critical careINFECTIOUS DISEASESLung DiseasesRespiratory infections

Identifiers

PMID38670599
PMCPMC11057316
OpenAlexW4395472451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.