Evidence map›Paper›PMID 38670280›Full record

ReviewGastroenterology2024

New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease.

Valérie Abadie, Arnold S Han, Bana Jabri, Ludvig M Sollid

Open access · bronzeAbstract readReview
In one paragraph

Review in Gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 47 citations in OpenAlex.

  1. Combined ProbioticMolecules (Basel, Switzerland) · 2026
    Trial
  2. Trial
  3. Gut microbes · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Functional immune profiling reveals CD4Immunology and cell biology · 2026
    Article
  8. IgA Subclasses and Free Light Chains in Celiac Disease: A Pilot Study.International journal of molecular sciences · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Review
  16. Article
  17. Frontiers in immunology · 2026
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Valérie AbadieDepartment of Medicine, University of Chicago, Chicago, Illinois; Section of Gastroenterology, Nutrition and Hepatology, University of Chicago, Chicago, Illinois; Committee on Immunology, University of Chicago, Chicago, Illinois. Electronic address: vabadie@bsd.uchicago.edu.
Arnold S HanColumbia Center for Translational Immunology, Columbia University, New York, New York; Department of Microbiology and Immunology, Columbia University, New York, New York; Department of Medicine, Digestive and Liver Diseases, Columbia University, New York, New York.
Bana JabriDepartment of Medicine, University of Chicago, Chicago, Illinois; Section of Gastroenterology, Nutrition and Hepatology, University of Chicago, Chicago, Illinois; Committee on Immunology, University of Chicago, Chicago, Illinois; Department of Pathology, University of Chicago, Chicago, Illinois; Department of Pediatrics, University of Chicago, Chicago, Illinois.
Ludvig M SollidNorwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
University of Illinois Chicago · USColumbia University Irving Medical Center · USOslo University Hospital · NO

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Tissue destruction and healing in Celiac DiseaseRC2DK133947 · NIDDK · UNIVERSITY OF CHICAGO · PI Luis Bruno Barreiro, RUSTEM F ISMAGILOV · 2022 to 2026
$11.9M
Role of Transglutaminase 2 in Celiac SprueR01DK063158 · NIDDK · STANFORD UNIVERSITY · PI CHAITAN KHOSLA · 2003 to 2026
$11.2M
Innate and adaptive immunity in celiac diseaseR01DK067180 · NIDDK · UNIVERSITY OF CHICAGO · PI JABRI, BANA · 2005 to 2024
$8.5M
Viral infections and celiac disease pathogenesisR01DK098435 · NIDDK · UNIVERSITY OF CHICAGO · PI DERMODY, TERENCE S., JABRI, BANA · 2014 to 2022
$5.4M
B cell-T cell crosstalk in celiac diseaseR01DK128352 · NIDDK · UNIVERSITY OF CHICAGO · PI ABADIE, VALERIE · 2021 to 2025
$2.1M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK063158NIDDK NIH HHS R01 DK067180NIDDK NIH HHS R01 DK098435NIDDK NIH HHS R01 DK128352NIDDK NIH HHS R01 DK138072NIDDK NIH HHS RC2 DK133947
6 · The paper itself

Abstract

Celiac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals upon consumption of cereal gluten proteins. It is a unique and complex immune disorder to study as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical, and immunologic studies, which together have revealed mechanisms of gluten peptide modification and HLA binding, thereby enabling a maladapted anti-gluten immune response. Observations in human samples combined with experimental mouse models have revealed that the gluten-induced immune response involves CD4

Indexed as

Celiac DiseaseGenetic Predisposition to DiseaseGlutensAnimalsB-LymphocytesCD4-Positive T-LymphocytesHumansGlutensB CellsCD4(+) T CellsCeliac DiseaseGlutenHLAIntraepithelial CD8(+) T CellsTransglutaminase 2Villous Atrophy

Identifiers

PMID38670280
PMCPMC11283582
OpenAlexW4395085219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.