Evidence map›Paper›PMID 38670235›Full record

ArticleThe Journal of allergy and clinical immunology2024

Alzheimer incidence and prevalence with and without asthma: A Medicare cohort study.

Christie M Bartels, Yi Chen, W Ryan Powell, Melissa A Rosenkranz, Barbara B Bendlin, Joseph Kramer, William W Busse, Amy Kind

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christie M BartelsRheumatology Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis; Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wis. Electronic address: cb4@medicine.wisc.edu.
Yi ChenDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
W Ryan PowellCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wis; Geriatrics Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Melissa A RosenkranzDepartment of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wis; Center for Healthy Minds, University of Wisconsin-Madison, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Barbara B BendlinCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wis; Geriatrics Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Joseph KramerCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
William W BusseDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Amy KindCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wis; Geriatrics Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
University of Wisconsin–Madison · US

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
Asthmatic Inflammation and Neurocircuitry ActivationR01HL123284 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BUSSE, WILLIAM W. · 2016 to 2019
$2.9M
Neighborhood Socioeconomic Disadvantage and Medicare's 30-Day Rehospitalization Policy: Eliminating Rehospitalization Disparities by Informing Policy Design and ImplementationR01MD010243 · NIMHD · UNIVERSITY OF WISCONSIN-MADISON · PI KIND, AMY J. · 2015 to 2019
$2.8M
Investigating the mechanisms by which systemic inflammation promotes Alzheimer’s disease: Asthma as a model and modifiable risk factorRF1AG082215 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N, ROSENKRANZ, MELISSA A · 2023 to 2023
$2.3M
NHLBI NIH HHS R01 HL123284NIA NIH HHS P30 AG062715NIA NIH HHS RF1 AG082215NIMHD NIH HHS R01 MD010243
6 · The paper itself

Abstract

backgroundInternational data suggest that asthma, like other inflammatory diseases, might increase Alzheimer disease (AD) risk.

objectiveWe sought to explore risk pathways and future mitigation strategies by comparing diagnostic claims-based AD incidence and prevalence among US patients with asthma with those without asthma.

methodsThis cohort study included a national Medicare 20% random sample (2013-2015). Adult patients with asthma with more than 12 months continuous Medicare were compared with subjects without asthma overall and as matched. Asthma was defined by 1 inpatient or 2 outpatient codes for asthma. The main outcomes were 2-year incident or prevalent AD defined by International Classification of Diseases, Ninth Revision code 331.0 or Tenth Revision code G30.0, G30.1, G30.8, or G30.9.

resultsAmong 5,460,732 total beneficiaries, 678,730 patients were identified with baseline asthma and more often identified as Black or Hispanic, were Medicaid eligible, or resided in a highly disadvantaged neighborhood than those without asthma. Two-year incidence of AD was 1.4% with asthma versus 1.1% without asthma; prevalence was 7.8% versus 5.4% (both P ≤ .001). Per 100,000 patients over 2 years, 303 more incident AD diagnoses occurred in those with asthma, with 2,425 more prevalent cases (P < .001). Multivariable models showed that asthma had greater odds of 2-year AD incidence (adjusted odds ratio, 1.33 [95% CI, 1.29-1.36]; matched 1.2 [95% CI, 1.17-1.24]) and prevalence (adjusted odds ratio, 1.48 [95% CI, 1.47-1.50]; matched 1.25 [95% CI, 1.22-1.27]).

conclusionsAsthma was associated with 20% to 33% increased 2-year incidence and 25% to 48% increased prevalence of claims-based AD in this nationally representative US sample. Future research should investigate risk pathways of underlying comorbidities and social determinants as well as whether there are potential asthma treatments that may preserve brain health.

Indexed as

Alzheimer DiseaseAsthmaMedicareAgedAged, 80 and overCohort StudiesFemaleHumansIncidenceMaleMiddle AgedPrevalenceRisk FactorsUnited StatesAlzheimerAsthmaclaims-based datacohort studyobservational studysystemic inflammation

Identifiers

PMID38670235
PMCPMC11305945
OpenAlexW4395085532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.