Evidence map›Paper›PMID 38670224›Full record

ReviewBrain stimulation

ITRUSST consensus on standardised reporting for transcranial ultrasound stimulation.

Eleanor Martin, Jean-François Aubry, Mark Schafer, Lennart Verhagen, Bradley Treeby, Kim Butts Pauly

Registry-linked trialAbstract readReviewConsensus Statement
In one paragraph

Review in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06518785 (Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06518785 narecruitingnot on this map

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

TypeinterventionalSponsorUniversity of California, San FranciscoRan2025 to 2030Enrolled25ConditionsAlcohol Use DisorderArmsLow Intensity Focused Ultrasound
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Neuromodulation of the central nervous system for facial pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. 2 mA is NOT 2 mA: Electric field variability in high-definition tDCS and its implications for precision neuromodulation in aging.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Eleanor MartinDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK.
Jean-François AubryPhysics for Medicine Paris, Inserm U1273, ESPCI Paris, CNRS UMR8063, PSL University, Paris, France.
Mark SchaferSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
Lennart VerhagenDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GD Nijmegen, The Netherlands.
Bradley TreebyDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Kim Butts PaulyDepartment of Radiology, Stanford University, Stanford, CA, USA. Electronic address: kimbutts@stanford.edu.

Funding

Neurostimulation by Ultrasound: Physical, Biophysical, and Neural MechanismsR01NS112152 · NINDS · STANFORD UNIVERSITY · PI BACCUS, STEPHEN A, BUTTS-PAULY, KIM · 2020 to 2024
$4.9M
Step 1 in Designing Appropriate Shams and Controls in Human TUSR01MH131684 · NIMH · STANFORD UNIVERSITY · PI Kim Butts Pauly · 2023 to 2026
$2.6M
What are we Stimulating with Transcranial Ultrasound in Mice?RF1MH116977 · NIMH · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM · 2018 to 2018
$1.8M
NIMH NIH HHS R01 MH131684NIMH NIH HHS RF1 MH116977NINDS NIH HHS R01 NS112152Wellcome Trust
6 · The paper itself

Abstract

As transcranial ultrasound stimulation (TUS) advances as a precise, non-invasive neuromodulatory method, there is a need for consistent reporting standards to enable comparison and reproducibility across studies. To this end, the International Transcranial Ultrasonic Stimulation Safety and Standards Consortium (ITRUSST) formed a subcommittee of experts across several domains to review and suggest standardised reporting parameters for low intensity TUS, resulting in the guide presented here. The scope of the guide is limited to reporting the ultrasound aspects of a study. The guide and supplementary material provide a simple checklist covering the reporting of: (1) the transducer and drive system, (2) the drive system settings, (3) the free field acoustic parameters, (4) the pulse timing parameters, (5) in situ estimates of exposure parameters in the brain, and (6) intensity parameters. Detailed explanations for each of the parameters, including discussions on assumptions, measurements, and calculations, are also provided.

Indexed as

BrainHumansUltrasonic TherapyStandardised reportingTranscranial ultrasound neuromodulationTranscranial ultrasound stimulationTUS

Identifiers

PMID38670224
PMCPMC12436198

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.