ReviewStem cell reports2024
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility.
Erratum issuedAbstract readReview
In one paragraph
Review in Stem cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nanomaterials targeting ferroptosis for osteoarthritis treatment: a systematic review of preclinical evidence.Journal of nanobiotechnology · 2026Pooled it
- Reconstructing AF-associated atrial fibrosis: Patient-specific iPSC models, fit-for-purpose atrial microphysiological systems, and nanomedicine.Materials today. Bio · 2026Review
- Engineering Lung-on-a-chip microdevices for respiratory disease modelling and drug testing: A fit-for-purpose framework for design and translational validation.Biomedical microdevices · 2026Review
- PK-Informed Microphysiological Systems: From Dynamic Dosing to Quantitative In Vitro-In Vivo Translation.Pharmaceutics · 2026Review
- Biobanked Liver Organoids: A Roadmap for Precision Hepatology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Integrative circulatory engineering for regenerative therapy: Dynamic perfusion design and metabolic maturation in cardiac tissue engineering.Regenerative therapy · 2026Article
- New Frontiers of Drug Development Through the Use of New Approach Methodologies.The AAPS journal · 2026Review
- A Microfluidic Framework for Neuroprotective Compound Triage Across Ischemia and Neurodegeneration.Molecules (Basel, Switzerland) · 2026Review
- Hydrogels for Bone Repair: Construction Strategies and Applications.Smart medicine · 2026Review
- Human Organoids and Organ-on-Chip for Biotoxin Assessment: Applications, Best Practices, and a Translational Roadmap.Toxins · 2026Review
- Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation.Biosensors · 2026Review
- Strategies to control cellular spatial organization in microphysiological systems.Microsystems & nanoengineering · 2026Review
- In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems.Microsystems & nanoengineering · 2026Review
- Mechano-Organ-on-Chip for Cancer Research.International journal of molecular sciences · 2026Review
- An organoid-guided roadmap for precision delivery of epigallocatechin gallate in oral submucous fibrosis.Frontiers in bioengineering and biotechnology · 2026Review
- Female Reproductive Tract Modeling through Advanced 3D Biomimetic Platforms.Biomaterials research · 2026Review
- Enhancing therapeutic strategies and drug development for patients with kidney disease.Expert opinion on drug safety · 2026Review
- Potential of organ-on-a-chip in advancing synthetic extracellular matrix technology for bone tissue engineering in dentistry (Review).Biomedical reports · 2026Review
- Independent testing infrastructure for new approach methodologies: the UC Davis NAMs testing center.Frontiers in medical technology · 2026Article
- Engineering osteoporosis-related bone organoids: a mechanism-module-functional readout framework for disease modelling and biomarker translation.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
David PamiesDepartment of Biomedical Science, University of Lausanne, Lausanne, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland. Electronic address: david.pamies@unil.ch.
Jason EkertJason E Ekert: UCB Pharma, Cambridge, MA, USA.
Marie-Gabrielle ZurichDepartment of Biomedical Science, University of Lausanne, Lausanne, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland.
Olivier FreyInSphero AG, Schlieren, Switzerland.
Sophie WernerSwiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland; University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Muttenz, Switzerland; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Monica PiergiovanniEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Benjamin S FreedmanDivision of Nephrology, Kidney Research Institute, and Institute for Stem Cell and Regenerative Medicine, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Plurexa LLC, Seattle, WA 98109, USA.
Adrian Kee Keong TeoStem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Proteos, Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Precision Medicine Translational Research Programme (TRP), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Hendrik ErfurthTissUse GmbH, Berlin, Germany.
Darwin R ReyesNational Institute of Standards and Technology, Gaithersburg, MD, USA.
Peter LoskillNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany; Department for Microphysiological Systems, Institute of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany; 3R Center for In Vitro Models and Alternatives to Animal Testing, Eberhard Karls University Tübingen, Tübingen, Germany.
Pelin Candarlioglu3D and 3Rs Ltd., 115c Milton Road, Cambridge CB4 1XE, UK.
Laura Suter-DickSwiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland; University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Muttenz, Switzerland.
Shan WangDepartment of Biomedical Science, University of Lausanne, Lausanne, Switzerland.
Thomas HartungDoerenkamp-Zbinden Professor and Chair for Evidence-based Toxicology, Johns Hopkins Bloomberg School of Public Health and Whiting School of Engineering, Baltimore, MD, USA; CAAT Europe, University of Konstanz, Konstanz, Germany.
Sandra CoeckeEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Glyn N StaceyInternational Stem Cell Banking Initiative, 2 High Street, Barley, Herts SG88HZ, UK; National Stem Cell Resource Centre, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China; Institute for Stem Cell and Regenerative Merdicine, Chinese Academy of Sciences, Beijing 100101, China.
Beren Atac WageggTissUse GmbH, Berlin, Germany.
Eva-Maria DehneTissUse GmbH, Berlin, Germany.
Francesca PistollatoHumane Society International, Rue Belliard 40, 1040 Bruxelles, Belgium.
Marcel LeistCAAT Europe, University of Konstanz, Konstanz, Germany; In vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.
Funding
Translational center for kidney microphysiological systems to improve drug safety and efficacyU2CTR004867 · NCATS · UNIVERSITY OF WASHINGTON · PI Benjamin Solomon Freedman, Jonathan Himmelfarb · 2024 to 2026
$4.8MCell specific delivery of novel therapies to enhance glomerular regeneration and repairUC2DK126006 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2020 to 2024
$4.0MSafety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological SystemsUH3TR003288 · NCATS · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON, HIMMELFARB, JONATHAN · 2022 to 2024
$2.3MSCGE Comparative Studies SupplementU01DK127553 · NIDDK · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON · 2020 to 2022
$2.2MA Human Organoid Model of Polycystic Kidney DiseaseR01DK117914 · NIDDK · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON · 2018 to 2022
$1.8MMechanisms of Kidney Injury in COVID-19R01DK130386 · NIDDK · UNIVERSITY OF WASHINGTON · PI AKILESH, SHREERAM, FREEDMAN, BENJAMIN SOLOMON · 2021 to 2023
$1.2MUtility of Human Organoids for Safety and Efficiency Evaluations of Genome Editing TherapeuticsU01AI176460 · NIAID · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON · 2023 to 2025
$1.0MNCATS NIH HHS UH3 TR003288NIAID NIH HHS U01 AI176460NIDDK NIH HHS R01 DK117914NIDDK NIH HHS R01 DK130386NIDDK NIH HHS U01 DK127553NIDDK NIH HHS UC2 DK126006
Abstract
Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological systems (MPSs), closely replicate tissue environments and human physiology, enhancing research and biomedical uses. However, MPS complexity introduces standardization challenges, impacting reproducibility and trust. We offer guidelines for quality management and control criteria specific to MPSs, facilitating reliable outcomes without stifling innovation. Our fit-for-purpose recommendations provide actionable advice for achieving consistent MPS performance.
Indexed as
Cell Culture TechniquesHumansMicrophysiological SystemsOrganoidsQuality ControlReproducibility of Resultscriteriain vitromicrophysiological systemsorganoidsorgan on chipquality controlrecommendationsreproducibilityspheroidsstandards
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.