Evidence map›Paper›PMID 38670108›Full record

ReviewCell metabolism2024

Immunological regulation of skeletal muscle adaptation to exercise.

P Kent Langston, Diane Mathis

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07497425 (Neuroimmune Responses to Physical Exercise Training in Chronic Primary Low Back Pain), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07497425 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neuroimmune Responses to Physical Exercise Training in Chronic Primary Low Back Pain

TypeinterventionalSponsorMcGill UniversityRan2025 to 2029Enrolled216ConditionsChronic Low Back Pain (CLBP)ArmsPhysical Exercise
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Effects of LCNutrients · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. The Crucial Role of Exercise in Promoting Adolescent Muscle Development.Advances in experimental medicine and biology · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

P Kent LangstonDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dm@hms.harvard.edu.
Harvard University · US

Funding

Muscle Tregs in health and diseaseR01AR070334 · NIAMS · HARVARD MEDICAL SCHOOL · PI MATHIS, DIANE J · 2016 to 2025
$3.7M
Muscle regulatory T cells in exercise and agingF32AG072874 · NIA · HARVARD MEDICAL SCHOOL · PI LANGSTON, PAUL KENT · 2021 to 2023
$210k
NIAMS NIH HHS R01 AR070334NIA NIH HHS F32 AG072874
6 · The paper itself

Abstract

Exercise has long been acknowledged for its powerful disease-preventing, health-promoting effects. However, the cellular and molecular mechanisms responsible for the beneficial effects of exercise are not fully understood. Inflammation is a component of the stress response to exercise. Recent work has revealed that such inflammation is not merely a symptom of exertion; rather, it is a key regulator of exercise adaptations, particularly in skeletal muscle. The purpose of this piece is to provide a conceptual framework that we hope will integrate exercise immunology with exercise physiology, muscle biology, and cellular immunology. We start with an overview of early studies in the field of exercise immunology, followed by an exploration of the importance of stromal cells and immunocytes in the maintenance of muscle homeostasis based on studies of experimental muscle injury. Subsequently, we discuss recent advances in our understanding of the functions and physiological relevance of the immune system in exercised muscle. Finally, we highlight a potential immunological basis for the benefits of exercise in musculoskeletal diseases and aging.

Indexed as

Adaptation, PhysiologicalExerciseMuscle, SkeletalAnimalsHumansInflammationexercisemuscleTregs

Identifiers

PMID38670108
PMCPMC11153001
OpenAlexW4395451194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.