Evidence map›Paper›PMID 38669528›Full record

ArticleJournal of Alzheimer's disease : JAD2024

Real World Financial Mismanagement in Alzheimer's Disease, Frontotemporal Dementia, and Primary Progressive Aphasia.

Sang Ngo, Ashley J Jackson, Madhumitha Manivannan, J Clayton Young, Brandon Leggins, Noah G Cryns, Sheila T Tran, Harli E Grant, Marguerite V Knudtson, Winston Chiong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sang NgoMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Ashley J JacksonMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Madhumitha Manivannan
J Clayton YoungMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Brandon LegginsMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Noah G CrynsMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Sheila T TranMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Harli E GrantMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Marguerite V KnudtsonMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Winston ChiongMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
University of California, San Francisco · USUniversity Memory and Aging Center · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Decision-Making in Genetic FTDR01AG022983 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIONG, WINSTON · 2004 to 2021
$6.0M
Decision-making abilities in Alzheimer's Disease and related dementias: From clinical standards to decision neuroscienceR01AG058817 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIONG, WINSTON · 2018 to 2022
$3.4M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG022983NIA NIH HHS R01 AG058817
6 · The paper itself

Abstract

Background: Whereas clinical experience in dementia indicates high risk for financial mismanagement, there has been little formal study of real world financial errors in dementia. Objective: We aimed to compare caregiver-reported financial mistakes among people with Alzheimer's disease, behavioral variant frontotemporal dementia (bvFTD), and primary progressive aphasia (PPA). Methods: Caregivers reported whether participants with dementia had made financial mistakes within the last year; and if so, categorized these as resulting from: (a) being too trusting or gullible, (b) being wasteful or careless with money, or (c) trouble with memory. In a pre-registered analysis https://archive.org/details/osf-registrations-vupj7-v1), we examined the hypotheses that (1) financial mistakes due to impaired socioemotional function and diminished sensitivity to negative outcomes are more prevalent in bvFTD than in Alzheimer's disease, and (2) financial mistakes due to memory are more prevalent in Alzheimer's disease than in bvFTD. Exploratory analyses addressed vulnerability in PPA and brain-behavior relationships using voxel-based morphometry. Results: Concordant with our first hypothesis, bvFTD was more strongly associated than Alzheimer's disease with mistakes due to being too trusting/gullible or wasteful/careless; contrary to our second hypothesis, both groups were similarly likely to make mistakes due to memory. No differences were found between Alzheimer's disease and PPA. Exploratory analyses indicated associations between financial errors and atrophy in right prefrontal and insular cortex. Conclusions: Our findings cohere with documented socioemotional and valuation impairments in bvFTD, and with research indicating comparable memory impairment between bvFTD and Alzheimer's disease.

Indexed as

Alzheimer DiseaseAphasia, Primary ProgressiveFrontotemporal DementiaAgedCaregiversFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsAlzheimer’s diseasedecision makingfinancial activitiesfinancial managementfrontotemporal dementiaprimary progressive aphasia

Identifiers

PMID38669528
PMCPMC11132181
OpenAlexW4395661487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.