ArticleScience advances2024
A vast repertoire of secondary metabolites potentially influences community dynamics and biogeochemical processes in cold seeps.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- High diversity but limited expression of biosynthetic gene clusters in a peatland microbial community.Nature communications · 2026Article
- Diverse biosynthetic pathways in Arctic hydrothermal biofilms.Nature communications · 2026Article
- The patterns of microbial community distribution and co-occurrence in water columns and sediments of Haima cold seep.Microbiology spectrum · 2026Article
- Multi-Omics Reveal Extracellular Electron Transfer Mechanism Under Deep-Sea High Salinity.Environmental microbiology · 2026Article
- Genomic and metabolomic characterization of Acinetobacter calcoaceticus (DT1) and Citrobacter braakii (S10) reveal functional traits for plant stress alleviation and sustainable agriculture.Functional & integrative genomics · 2026Article
- Wringing everything out with bioprospecting.Nature reviews. Microbiology · 2026Article
- High molecular weight dissolved organic matter drives soil resistome proliferation by enhancing microbial competition and viral carbon metabolism.The ISME journal · 2026Article
- Co-occurrence of diverse defense systems shapes complex microbe-virus relationships in deep-sea cold seeps.Nature communications · 2026Article
- Exploring the Biosynthetic Potential of Microorganisms from the South China Sea Cold Seep Using Culture-Dependent and Culture-Independent Approaches.Marine drugs · 2025Article
- The risk of pathogenicity and antibiotic resistance in deep-sea cold seep microorganisms.mSystems · 2025Article
- Cold seeps are potential hotspots of deep-sea nitrogen loss driven by microorganisms across 21 phyla.Nature communications · 2025Article
- Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails.Microbiome · 2025Article
- Deep-Sea Ecosystems as an Unexpected Source of Antibiotic Resistance Genes.Marine drugs · 2024Article
- Eremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived FungusMarine drugs · 2024Article
- Article
- The HOMO-LUMO Gap as Discriminator of Biotic from Abiotic Chemistries.Life (Basel, Switzerland) · 2024Article
- Revealing the metabolic potential and environmental adaptation of nematophagous fungus,Frontiers in microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In deep-sea cold seeps, microbial communities thrive on the geological seepage of hydrocarbons and inorganic compounds, differing from photosynthetically driven ecosystems. However, their biosynthetic capabilities remain largely unexplored. Here, we analyzed 81 metagenomes, 33 metatranscriptomes, and 7 metabolomes derived from nine different cold seep areas to investigate their secondary metabolites. Cold seep microbiomes encode diverse and abundant biosynthetic gene clusters (BGCs). Most BGCs are affiliated with understudied bacteria and archaea, including key mediators of methane and sulfur cycling. The BGCs encode diverse antimicrobial compounds that potentially shape community dynamics and various metabolites predicted to influence biogeochemical cycling. BGCs from key players are widely distributed and highly expressed, with their abundance and expression levels varying with sediment depth. Sediment metabolomics reveals unique natural products, highlighting uncharted chemical potential and confirming BGC activity in these sediments. Overall, these results demonstrate that cold seep sediments serve as a reservoir of hidden natural products and sheds light on microbial adaptation in chemosynthetically driven ecosystems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.