Evidence map›Paper›PMID 38669186›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Dissection and integration of bursty transcriptional dynamics for complex systems.

Cheng Frank Gao, Suriyanarayanan Vaikuntanathan, Samantha J Riesenfeld

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Dissection and integration of bursty transcriptional dynamics for complex systems.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Cheng Frank GaoDepartment of Chemistry, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-3296-773X
Suriyanarayanan Vaikuntanathan *Department of Chemistry, University of Chicago, Chicago, IL 60637.
Samantha J Riesenfeld *Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-9144-021X

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
Elucidating biophysical mechanisms for force sensing and control using non-equilibrium statistical mechanics and AIR35GM147400 · NIGMS · UNIVERSITY OF CHICAGO · PI Suriyanarayanan Vaikuntanathan · 2022 to 2026
$1.9M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK138072NIGMS NIH HHS R35 GM147400
6 · The paper itself

Abstract

RNA velocity estimation is a potentially powerful tool to reveal the directionality of transcriptional changes in single-cell RNA-sequencing data, but it lacks accuracy, absent advanced metabolic labeling techniques. We developed an approach,

Indexed as

Cell DifferentiationLatent Class AnalysisSingle-Cell Gene Expression AnalysisTranscription, GeneticAnimalsDatasets as TopicDevelopmental BiologyHematopoiesisHumansImmunity, InnateInflammationLymphocytesMiceProbabilityReproducibility of ResultsSkinprobabilistic topic modelsRNA velocitysingle-cell RNA-seqsystems immunologytrajectory inference

Identifiers

PMID38669186
PMCPMC11067469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.