Evidence map›Paper›PMID 38669055›Full record

ArticleThe Journal of organic chemistry2024

Direct Synthesis of Glycosyl Chlorides from Thioglycosides.

Daniel J Hoard, Yogesh Sutar, Alexei V Demchenko

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel J HoardDepartment of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, Missouri 63103, United States.
Yogesh SutarDepartment of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, Missouri 63103, United States.
Alexei V DemchenkoDepartment of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, Missouri 63103, United States.ORCID 0000-0003-3515-212X

Funding

Automation of the chemical synthesis of human milk oligosaccharidesR01GM111835 · NIGMS · SAINT LOUIS UNIVERSITY · PI DEMCHENKO, ALEXEI V · 2014 to 2023
$2.5M
Methods and technologies for chemical synthesis of glycansR35GM152125 · NIGMS · SAINT LOUIS UNIVERSITY · PI ALEXEI V DEMCHENKO · 2024 to 2026
$1.2M
NIGMS NIH HHS R01 GM111835NIGMS NIH HHS R35 GM152125
6 · The paper itself

Abstract

Reported herein is a new method for the direct synthesis of glycosyl chlorides from thioglycosides using sulfuryl chloride at rt. A variety of thioglycosides and thioimidates could be used as substrates. Both acid- and base-sensitive protecting groups were found compatible with these reaction conditions. Preliminary investigation of the reaction mechanism indicates chlorination of the leaving group at the anomeric sulfur as the key step of the reaction.

Indexed as

ChloridesThioglycosidesGlycosidesGlycosylationMolecular StructureChloridesGlycosidesThioglycosides

Identifiers

PMID38669055
PMCPMC11555473

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.