Evidence map›Paper›PMID 38668982›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Bioinformatic Prohormone Discovery in Basal Metazoans: Insights from Trichoplax.

Mikhail A Nikitin, Daria Y Romanova, Leonid L Moroz

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mikhail A NikitinBelozersky Institute for Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation.
Daria Y RomanovaInstitute of Higher Nervous Activity and Neurophysiology of RAS, Moscow, Russian Federation.
Leonid L MorozDepartment of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, USA. moroz@whitney.ufl.edu.

Funding

Neuron-SELEX: Development of neuron-specific nanoscale toolkits for single-cell recognitionR01NS114491 · NINDS · UNIVERSITY OF FLORIDA · PI MOROZ, LEONID L · 2020 to 2024
$2.0M
NINDS NIH HHS R01 NS114491
6 · The paper itself

Abstract

Experimental discovery of neuropeptides and peptide hormones is a long and tedious task. Mining the genomic and transcriptomic sequence data with robust secretory peptide prediction tools can significantly facilitate subsequent experiments. We describe the application of various in silico neuropeptide discovery methods for the placozoan Trichopax adhaerens as an illustrated example and a powerful experimental paradigm for cellular and evolutionary biology. In total, 33 placozoan (neuro)peptide-like hormone precursors were found using homology-based BLAST search and repeat-based and comparative evolutionary methods. Some of the discovered precursors are homologous to insulins and RFamide precursors from Cnidaria and other animal phyla.

Indexed as

Computational BiologyNeuropeptidesPlacozoaAmino Acid SequenceAnimalsEvolution, MolecularPhylogenyNeuropeptidesBasal metazoansBehaviorCnidariaCtenophoraNervous system evolutionNeuropeptidesPlacozoaProhormone processingSecretory moleculesSignaling

Identifiers

PMID38668982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.