Evidence map›Paper›PMID 38668865›Full record

SynthesisStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2024

Potential Single Nucleotide Polymorphisms markers for radiation dermatitis in head and neck cancer patients: a meta-analysis.

Beatriz Regina Lima Aguiar, Elaine Barros Ferreira, Ana Gabriela Costa Normando, Sabrina Dos Santos Dias, Eliete Neves Silva Guerra, Paula Elaine Diniz Reis

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07149506 (Efficacy of Oral or Topical Catechins vs. Placebo as an Adjuvant for the Prevention and Management of Radiation Dermatitis in Oncology Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07149506 phase3enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Efficacy of Oral or Topical Catechins vs. Placebo as an Adjuvant for the Prevention and Management of Radiation Dermatitis in Oncology Patients: a Randomized Trial

TypeinterventionalSponsorCARLOS FRANCISCO SAAVEDRA GARCIARan2025 to 2027Enrolled162ConditionsRadiation Dermatitis Acute, Radiation Dermatitis, Fibrosis, SkinArmsEpicatechin, Epigallocatechin Gallate (EGCG), Microcrystalline Cellulose NF (placebo), Saline (0.9% NaCl)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beatriz Regina Lima AguiarHealth Science Graduate Program, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.ORCID 0000-0003-0394-0500
Elaine Barros FerreiraHealth Science Graduate Program, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.ORCID 0000-0003-0428-834X
Ana Gabriela Costa NormandoOral Diagnosis Department, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID 0000-0002-0307-4991
Sabrina Dos Santos DiasSuperior School of Health Sciences, Brasília, DF, Brazil.ORCID 0000-0001-7685-473X
Eliete Neves Silva GuerraLaboratory of Oral Histopathology, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.ORCID 0000-0002-7622-1550
Paula Elaine Diniz ReisNursing Department, School of Health Sciences, University of Brasilia, Brasília, DF, Brazil. pauladiniz@unb.br.ORCID 0000-0002-9782-3366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify potential Single Nucleotide Polymorphisms (SNPs) of susceptibility for the development of acute radiation dermatitis in head and neck cancer patients, and also to verify the association between SNPs and the severity of RD.

methodsThis systematic review was reported according to the PRISMA guideline. The proportion meta-analysis was performed to identify the prevalence of genetic markers by geographical region and radiation dermatitis severity. The meta-analysis was performed to verify the association between genetic markers and RD severity. The certainty of the evidence was assessed by GRADE.

resultsThirteen studies were included. The most prevalent SNPs were XRCC3 (rs861639) (36%), TGFβ1 (rs1800469) (35%), and RAD51 (rs1801321) (34%). There are prevalence studies in Europe and Asia, with a similar prevalence for all SNPs (29-40%). The prevalence was higher in patients who developed radiation dermatitis ≤2 for any subtype of genes (75-76%). No SNP showed a statistically significant association with very low certainty of evidence.

conclusionThe most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideRadiodermatitisGenetic MarkersHead and Neck NeoplasmsHumansRisk FactorsGenetic MarkersGenetic markersHead and neck neoplasms.RadiodermatitisRadiotherapySingle Nucleotide Polymorphism

Identifiers

PMID38668865

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.