Evidence map›Paper›PMID 38668821›Full record

ArticleProbiotics and antimicrobial proteins2025

Long-Term Treatment with Alcaligenes faecalis A12C Improves Host Resistance to Pathogens in Septic Rats: Possible Contribution of Curdlan-Like Immune Trainer.

C J Martel-Benítez, R Alayón-Afonso, D Padilla Castillo, F J Chamizo-López, M Isabel García-Laorden, A Espinosa de Los Monteros Y Zayas, J C Rivero-Vera, P Nogueira Salgueiro, F Real, A Bordes-Benítez and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

C J Martel-Benítez *Group of Fish health for aquaculture and wild species, Infectious diseases and Food safety, University Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416, Arucas, Spain.ORCID http://orcid.org/0000-0002-1580-4058
R Alayón-Afonso *Group of Fish health for aquaculture and wild species, Infectious diseases and Food safety, University Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416, Arucas, Spain.ORCID http://orcid.org/0000-0002-2928-0144
D Padilla CastilloGroup of Fish health for aquaculture and wild species, Infectious diseases and Food safety, University Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416, Arucas, Spain. daniel.padilla@ulpgc.es.ORCID http://orcid.org/0000-0002-6678-5029
F J Chamizo-LópezMicrobiology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de La Ballena s/n, 35019, Las Palmas de Gran Canaria, Spain.ORCID http://orcid.org/0000-0003-1328-1924
M Isabel García-LaordenCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain.ORCID http://orcid.org/0000-0001-6270-6306
A Espinosa de Los Monteros Y ZayasMorphology Department, University Institute of Animal Health and Food Safety (IUSA), Universidad de Las Palmas de Gran Canaria, Arucas, Las Palmas, Spain.ORCID http://orcid.org/0000-0002-7736-3139
J C Rivero-VeraPathology Service, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de La Ballena S/N, 35019, Las Palmas de Gran Canaria, Spain.ORCID http://orcid.org/0000-0003-3039-0030
P Nogueira SalgueiroClinical Biochemistry Department, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de La Ballena s/n, 35019, Las Palmas de Gran Canaria, Spain.ORCID http://orcid.org/0000-0002-8029-2685
F RealGroup of Fish health for aquaculture and wild species, Infectious diseases and Food safety, University Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416, Arucas, Spain.ORCID http://orcid.org/0000-0001-6526-0354
A Bordes-BenítezMicrobiology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de La Ballena s/n, 35019, Las Palmas de Gran Canaria, Spain.ORCID http://orcid.org/0000-0003-3243-7402
A Martel QuintanaBanco Español de Algas, Instituto de Oceanografía y Cambio Global, Universidad de Las Palmas de Gran Canaria, Telde, Spain.ORCID http://orcid.org/0000-0002-7450-0505
C Almeida PeñaBanco Español de Algas, Fundación Parque Científico Tecnológico, Universidad de Las Palmas de Gran Canaria, Telde, Spain.ORCID http://orcid.org/0000-0001-9283-4851
C Domínguez CabreraClinical Biochemistry Department, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de La Ballena s/n, 35019, Las Palmas de Gran Canaria, Spain.ORCID http://orcid.org/0000-0003-2600-1637
J M González-MartínStatistics Service, Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Barranco de La Ballena s/n, 35019, Las Palmas de Gran Canaria, Spain.ORCID http://orcid.org/0000-0001-6816-4157
J Martín CaballeroBarcelona, Biomedical Research Park (PRBB), Barcelona, Spain.ORCID http://orcid.org/0000-0002-1579-2739
R Frías BeneytoDeparment of Laboratory Medicine and Comparative Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7569-5693
Jesús VillarCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain.ORCID http://orcid.org/0000-0001-5687-3562
J L Martín-BarrasaGroup of Fish health for aquaculture and wild species, Infectious diseases and Food safety, University Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416, Arucas, Spain.ORCID http://orcid.org/0000-0002-3280-9838

Funding

Fundación Canaria Instituto de Investigación Sanitaria de Canarias PIFUN30/18Ministerio de Economía y Competitividad, Spain AGL2014-54683-R
6 · The paper itself

Abstract

Curdlan, a β-1,3/1,6-glucan found in Alcaligenes faecalis (A. faecalis) wall, activates innate and humoral immunity. The aim of this study is to evaluate whether pretreated rats with A. faecalis A12C could prevent sepsis disturbances and identify the immunomodulatory mechanisms involved. Experiments occurred in two stages: a survival study with 16 rats randomly divided into septic (SC) (n = 8) and septic pretreated (SA) (n = 8) groups and 45 rats divided into four groups: healthy (AGUSAN) (n = 9), septic (AGUIC) (n = 13), septic pretreated (AGUIA) (n = 14), and healthy pretreated (AGUSTO) (n = 9). Sepsis was induced by cecal ligation and puncture after 30 days of A. faecalis A12C pretreatment or without. SA group had a higher survival rate of 58% vs. 16% for SC group (P < 0.05). Overall, AGUIA showed better status than AGUIC (P < 0.01). Higher monocytosis was found in AGUIA and AGUSTO vs. AGUIC and AGUSAN, respectively (P < 0.05). A gradual increase in curdlan fecal concentration was observed in AGUIA during pretreatment. Fecal concentrations of Escherichia coli significantly decreased in AGUIA and AGUSTO. Bacterial load in urine, peritoneal lavage fluid (PLF), and bronchoalveolar lavage fluid (BALF) decreased (P < 0.05) in AGUIA vs. AGUIC. Finally, lower inflammation was observed in serum, BALF, and PLF, with reduced IL-6, IL-10, IL-1β, and TNF-α, along with less damage in lungs and peritoneum in AGUIA vs. AGUIC. These findings suggest the connection between curdlan-produced by A. faecalis A12C-with the immune system and the reduction in severity of experimental sepsis.

Indexed as

Alcaligenes faecalisbeta-GlucansSepsisAnimalsCytokinesMaleRatsRats, Wistarbeta-GlucanscurdlanCytokinesAlcaligenes faecalisCurdlanCytokinesProbioticRatSepsis

Identifiers

PMID38668821
PMCPMC12532692

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.