Evidence map›Paper›PMID 38668787›Full record

ArticleJournal of molecular neuroscience : MN2024

Behavioral and Metabolic Effects of ABCG4 KO in the APP

Vincent Fong, Babunageswararao Kanuri, Owen Traubert, Min Lui, Shailendra B Patel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vincent FongDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, OH, USA.
Babunageswararao KanuriDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, OH, USA.
Owen TraubertDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, OH, USA.
Min LuiDepartment of Pathology & Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.
Shailendra B PatelDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, OH, USA. sbpatel@ucmail.uc.edu.ORCID http://orcid.org/0000-0003-0046-5513
University of Cincinnati · US

Funding

The Role of Abcg4 in Alzheimer’s DiseaseR03AG063322 · NIA · UNIVERSITY OF CINCINNATI · PI PATEL, SHAILENDRA BHANUBHAI · 2019 to 2020
$321k
NIA NIH HHS R03 AG063322NIH HHS R03AG063322
6 · The paper itself

Abstract

The pathogenesis of Alzheimer's disease (AD) is complex and involves an imbalance between production and clearance of amyloid-ß peptides (Aß), resulting in accumulation of Aß in senile plaques. Hypercholesterolemia is a major risk factor for developing AD, with cholesterol shown to accumulate in senile plaques and increase production of Aß. ABCG4 is a member of the ATP-binding cassette transporters predominantly expressed in the CNS and has been suggested to play a role in cholesterol and Aß efflux from the brain. In this study, we bred Abcg4 knockout (KO) with the APP

Indexed as

Alzheimer DiseaseATP Binding Cassette Transporter, Subfamily GAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainMaleMiceMice, Inbred C57BLPlaque, AmyloidAbcg4 protein, mouseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorATP Binding Cassette Transporter, Subfamily GABCG4Alzheimer’s diseaseBehaviorCholesterol metabolismGlucose metabolism

Identifiers

PMID38668787
PMCPMC11052713
OpenAlexW4395676053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.