Evidence map›Paper›PMID 38668758›Full record

ReviewThe Journal of experimental medicine2024

Treg-tissue cell interactions in repair and regeneration.

Lucas F Loffredo, Thomas M Savage, Olivia R Ringham, Nicholas Arpaia

Erratum issuedOpen access · hybridAbstract readReview
In one paragraph

Review in The Journal of experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  10. Review
  11. Elevated ST2Arthritis research & therapy · 2026
    Article
  12. Review
  13. Article
  14. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lucas F Loffredo *Department of Microbiology and Immunology, Columbia University, New York, NY, USA.ORCID 0000-0002-0835-6496
Thomas M Savage *Department of Microbiology and Immunology, Columbia University, New York, NY, USA.ORCID 0000-0002-6618-2973
Olivia R Ringham *Department of Microbiology and Immunology, Columbia University, New York, NY, USA.ORCID 0000-0001-6715-8599
Nicholas ArpaiaDepartment of Microbiology and Immunology, Columbia University, New York, NY, USA.ORCID 0000-0002-0657-0528
Columbia University · USColumbia University Irving Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Lung leukocytes promote alveolar epithelial regeneration after severe injuryR01HL148718 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPAIA, NICHOLAS · 2020 to 2024
$3.2M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
Role of T cell-derived amphiregulin in recovery from influenza virus infectionR21AI149657 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPAIA, NICHOLAS · 2020 to 2021
$434k
Mechanisms mediating tissue repair by leukocytes during influenza virus infectionK22AI127847 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPAIA, NICHOLAS · 2017 to 2018
$266k
NHLBI NIH HHS R01 HL148718NHLBI NIH HHS R01HL148718NIAID NIH HHS K22 AI127847NIAID NIH HHS R21 AI149657NIAID NIH HHS T32 AI106711NIGMS NIH HHS T32 GM007367NIGMS NIH HHS T32GM007367
6 · The paper itself

Abstract

Regulatory T (Treg) cells are classically known for their critical immunosuppressive functions that support peripheral tolerance. More recent work has demonstrated that Treg cells produce pro-repair mediators independent of their immunosuppressive function, a process that is critical to repair and regeneration in response to numerous tissue insults. These factors act on resident parenchymal and structural cells to initiate repair in a tissue-specific context. This review examines interactions between Treg cells and tissue-resident non-immune cells-in the context of tissue repair, fibrosis, and cancer-and discusses areas for future exploration.

Indexed as

Cell CommunicationRegenerationT-Lymphocytes, RegulatoryAnimalsFibrosisHumansNeoplasmsWound Healing

Identifiers

PMID38668758
PMCPMC11046849
OpenAlexW4395665807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.