Evidence map›Paper›PMID 38668648›Full record

ArticleMilitary medicine2024

The Role of Mental Health Conditions in Early Detection and Treatment of Veterans With Alzheimer's Dementia.

Maureen K O'Connor, Byron J Aguilar, Andrew Nguyen, Dan Berlowitz, Raymond Zhang, Amir Abbas Tahami Monfared, Quanwu Zhang, Weiming Xia

Abstract read
In one paragraph

Article in Military medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maureen K O'ConnorGeriatric Research Education and Clinical Center, VA Bedford Healthcare System, Bedford, MA 01730, USA.
Byron J AguilarGeriatric Research Education and Clinical Center, VA Bedford Healthcare System, Bedford, MA 01730, USA.
Andrew NguyenGeriatric Research Education and Clinical Center, VA Bedford Healthcare System, Bedford, MA 01730, USA.ORCID 0000-0003-1165-6913
Dan BerlowitzZuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Raymond ZhangAlzheimer's Disease and Brain Health, Eisai Inc., Nutley, NJ 07110, USA.
Amir Abbas Tahami MonfaredAlzheimer's Disease and Brain Health, Eisai Inc., Nutley, NJ 07110, USA.
Quanwu ZhangAlzheimer's Disease and Brain Health, Eisai Inc., Nutley, NJ 07110, USA.
Weiming XiaGeriatric Research Education and Clinical Center, VA Bedford Healthcare System, Bedford, MA 01730, USA.ORCID 0000-0002-7463-3295

Funding

Big data and small molecules for Alzheimer's diseaseRF1AG063913 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOLDSTEIN, LEE E., XIA, WEIMING · 2019 to 2021
$2.9M
Eisai IncorporatedNIA NIH HHS RF1 AG063913NIH HHS RF1AG063913
6 · The paper itself

Abstract

introductionThe benefits of early detection of Alzheimer's disease (AD) have become increasingly recognized. Veterans with mental health conditions (MHCs) may be less likely to receive a specific AD diagnosis compared to veterans without MHCs. We investigated whether rates of MHCs differed between veterans diagnosed with unspecified dementia (UD) vs. AD to better understand the role MHCs might play in establishing a diagnosis of AD. MATERIALS AND

methodsThis retrospective analysis (2015-2022) identified UD and AD with diagnostic code-based criteria. We determined the proportion of veterans with MHCs in UD vs. AD cohorts. Secondarily, we assessed the distribution of UD/AD diagnoses in veterans with and without MHCs.

resultsWe identified 145,309 veterans with UD and 33,996 with AD. The proportion of each MHC was consistently higher in UD vs. AD cohorts: 41.4% vs. 33.2% (depression), 26.9% vs. 20.3% (post-traumatic stress disorder), 23.4% vs. 18.2% (anxiety), 4.3% vs. 2.1% (bipolar disorder), and 3.9% vs. 1.5% (schizophrenia). The UD diagnostic code was used in 84% of veterans with MHCs vs. 78% without MHCs (P < .001).

conclusionsMental health conditions were more likely in veterans with UD vs. AD diagnoses; comorbid MHC may contribute to delayed AD diagnosis.

Indexed as

Alzheimer DiseaseEarly DiagnosisVeteransAgedAged, 80 and overCohort StudiesDementiaFemaleHumansMaleMental DisordersMiddle AgedRetrospective StudiesUnited States

Identifiers

PMID38668648
PMCPMC11439997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.