Evidence map›Paper›PMID 38668220›Full record

ArticleNanomaterials (Basel, Switzerland)2024

Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin.

Luigi Talarico, Ilaria Clemente, Alessandro Gennari, Giulia Gabbricci, Simone Pepi, Gemma Leone, Claudia Bonechi, Claudio Rossi, Simone Luca Mattioli, Nicola Detta and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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  7. Encapsulation ofNanomaterials (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Luigi TalaricoDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-8553-3521
Ilaria ClementeDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-8357-7854
Alessandro GennariDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0009-0000-1570-9694
Giulia GabbricciDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0009-0001-7076-0852
Simone PepiDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-3290-9644
Gemma LeoneDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-0820-6068
Claudia BonechiDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-4328-3253
Claudio RossiDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0001-6032-1015
Simone Luca MattioliDompé Farmaceutici S.p.A, Via Campo di Pile SNC, 67100 L'Aquila, Italy.ORCID 0009-0001-1691-6115
Nicola DettaDompé Farmaceutici S.p.A, Via Campo di Pile SNC, 67100 L'Aquila, Italy.ORCID 0009-0007-0877-9839
Agnese MagnaniDepartment of Biotechnology Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-6960-9418
University of Siena · ITIBSA Farmaceutici (Italy) · IT

Funding

European Union - Next GenerationEU - PNRR M4C2 I1.5 B63C22000680 007
6 · The paper itself

Abstract

Natamycin is a tetraene polyene that exploits its antifungal properties by irreversibly binding components of fungal cell walls, blocking the growth of infections. However, topical ocular treatments with natamycin require frequent application due to the low ability of this molecule to permeate the ocular membrane. This limitation has limited the use of natamycin as an antimycotic drug, despite it being one of the most powerful known antimycotic agents. In this work, different lipidic nanoformulations consisting of transethosomes or lipid nanoparticles containing natamycin are proposed as carriers for optical topical administration. Size, stability and zeta potential were characterized via dynamic light scattering, the supramolecular structure was investigated via small- and wide-angle X-ray scattering and 1H-NMR, and the encapsulation efficiencies of the four proposed formulations were determined via HPLC-DAD.

Indexed as

encapsulationlipid nanoparticlesnatamycinNMRSAXSsupramolecular

Identifiers

PMID38668220
PMCPMC11053702
OpenAlexW4395012128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.