Evidence map›Paper›PMID 38668020›Full record

ArticleDentistry journal2024

Effects of Improper Mechanical Force on the Production of Sonic Hedgehog, RANKL, and IL-6 in Human Periodontal Ligament Cells In Vitro.

Erika Yamashita, Shinichi Negishi, Jun Kikuta, Mami Shimizu, Hidenobu Senpuku

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dentistry journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erika YamashitaDepartment of Orthodontics, Nihon University of School at Matsudo, Matsudo 271-8587, Japan.
Shinichi NegishiDepartment of Orthodontics, Nihon University of School at Matsudo, Matsudo 271-8587, Japan.
Jun KikutaDepartment of Orthodontics, Nihon University of School at Matsudo, Matsudo 271-8587, Japan.
Mami ShimizuDepartment of Orthodontics, Nihon University of School at Matsudo, Matsudo 271-8587, Japan.
Hidenobu SenpukuDepartment of Microbiology and Immunology, Nihon University of School at Matsudo, Matsudo 271-8587, Japan.ORCID 0000-0002-3915-1354
Nihon University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 16K11537 and 20K10286
6 · The paper itself

Abstract

Improper mechanical stress may induce side effects during orthodontic treatment. If the roots and alveolar bones are extensively resorbed following excess mechanical stress, unplanned tooth mobility and inflammation can occur. Although multiple factors are believed to contribute to the development of side effects, the cause is still unknown. Sonic hedgehog (Shh), one of the hedgehog signals significantly associated with cell growth and cancer development, promotes osteoclast formation in the jawbone. Shh may be associated with root and bone resorptions during orthodontic treatment. In this study, we investigated the relationships between Shh, RANKL, and IL-6 in human periodontal ligament (hPDL) cells exposed to improper mechanical force. Weights were placed on hPDL cells and human gingival fibroblasts (HGFs) for an optimal orthodontic force group (1.0 g/cm

Indexed as

hPDLIL-6RANKLsonic hedgehog

Identifiers

PMID38668020
PMCPMC11049549
OpenAlexW4394798563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.