ReviewJournal of functional biomaterials2024
Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades.
Review in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Radiographic choice for skeletal maturation assessment: a systematic review of Cervical Vertebrae Method and Middle Phalanx Method.Oral radiology · 2026Pooled it
- Bioactive surface modifications on dental implants: a systematic review and meta-analysis of osseointegration and longevity.Clinical oral investigations · 2024Pooled it
- Advances in TCP-Modified PMMA Bone Cements: Relating Microstructure to Mechanical, Biological and Functional Performance-Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Design and validation of a biomechanics device for preclinical arthrofibrosis models.Bone & joint research · 2026Article
- Mechanobiological Response of Peri-Implant Bone to Variations in Inter-Implant Distance: A Finite Element Analysis of Conometric Implants at Crestal and Subcrestal Positions.Journal of functional biomaterials · 2026Article
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Innovations in Implant Osseointegration: Biomaterials, Surface Engineering, and Translational Strategies.Journal of biomedical materials research. Part A · 2026Review
- Degenerative Gastrocnemius Muscle Changes in a Goat Tibial Ostectomy Model Persist 10 Months After Splint Removal.Muscles (Basel, Switzerland) · 2026Article
- Longitudinal and radial microgradients in porosity and canal diameter in femur bone and its implications for bone regeneration and bone repair implants.Frontiers in bioengineering and biotechnology · 2026Article
- Biomechanical behavior of two different surface treatments on dental implants with healing chambers in osteoporotic rabbits: an experimental study.Scientific reports · 2025Article
- Animal models in human surgery and implant innovation: ethical considerations and scientific advancements.Annals of medicine and surgery (2012) · 2025Article
- Early Osseointegration in a Sheep Tibia Model: Correlating Digital Periapical Radiograph Gray-Level and RGB-Derived Metrics with Histologic Tissue Composition.Journal of functional biomaterials · 2025Article
- Review
- Low Intensity Thermal Stimulation to Enhance Early Osteointegration in Implants: A Preclinical Study in Rabbits.Clinical and experimental dental research · 2025Article
- Eighty-Four-Month Clinical Outcomes of Autologous Dentin Graft Using Tooth TransformerJournal of functional biomaterials · 2025Article
- Impact of three-dimensional stabilization thread design on biomechanical fixation and osseointegration of endosteal implants.Journal of the mechanical behavior of biomedical materials · 2025Article
- Effect of insertion load on insertion torque value.Journal of dental sciences · 2025Article
- Effect of Ti6Al4V Alloy Surface and Porosity on Bone Osseointegration: In Vivo Pilot Study in Rabbits.Materials (Basel, Switzerland) · 2025Article
- Histomorphometric and microtomographic evaluation of hydroxyapatite coated implants and L-PRF in over drilled bone sites in sheep.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental implants and bone augmentation are among dentistry's most prevalent surgical treatments; hence, many dental implant surfaces and bone grafts have been researched to improve bone response. Such new materials were radiologically, histologically, and histomorphometrically evaluated on animals before being used on humans. As a result, several studies used animals to evaluate novel implant technologies, biocompatibility, surgical techniques, and osseointegration strategies, as preclinical research on animal models is essential to evaluate bioactive principles (on cells, compounds, and implants) that can act through multiple mechanisms and to predict animal behavior, which is difficult to predict from in vitro studies alone. In this study, we critically reviewed all research on different animal models investigating the osseointegration degree of new implant surfaces, reporting different species used in the osseointegration research over the last 30 years. Moreover, this is the first study to summarize reviews on the main animal models used in the translational research of osseointegration, including the advantages and limitations of each model and determining the ideal location for investigating osseointegration in small and large animal models. Overall, each model has advantages and disadvantages; hence, animal selection should be based on the cost of acquisition, animal care, acceptability to society, availability, tolerance to captivity, and housing convenience. Among small animal models, rabbits are an ideal model for biological observations around implants, and it is worth noting that osseointegration was discovered in the rabbit model and successfully applied to humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.