Evidence map›Paper›PMID 38667506›Full record

ArticleMedicines (Basel, Switzerland)2024

Improved Outcomes in Eosinophilic Esophagitis with Higher Medication Possession Ratio.

Nathan T Kolasinski, Eric A Pasman, Cade M Nylund, Patrick T Reeves, Daniel I Brooks, Katerina G Lescouflair, Steve B Min

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicines (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathan T KolasinskiDepartment of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.ORCID 0000-0002-4902-9352
Eric A PasmanDepartment of Pediatrics, Uniformed Services University, Bethesda, MD 20889, USA.
Cade M NylundDepartment of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.ORCID 0000-0003-4543-6804
Patrick T ReevesDepartment of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Daniel I BrooksDepartment of Research Programs, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Katerina G LescouflairDepartment of Research Programs, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Steve B MinDepartment of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic esophagitis (EoE) disease activity can be caused by treatment non-adherence. Medication possession ratio (MPR) is an established metric of medication adherence. A higher MPR correlates with better outcomes in several chronic diseases, but MPR has not been investigated with respect to EoE. A retrospective cohort study was performed using an established EoE registry for the years 2005 to 2020. Treatment periods were identified, MPRs were calculated, and medical records were assessed for histologic remission (<15 eos/hpf), dysphagia, food impaction, stricture occurrence, and esophageal dilation that corresponded to each treatment period. In total, 275 treatment periods were included for analysis. The MPR in the histologic remission treatment period group was 0.91 (IQR 0.63-1) vs. 0.63 (IQR 0.31-0.95) for the non-remission treatment period group (

Indexed as

adherencecompliancecosteosinophilic esophagitismedication possession ratiosafety

Identifiers

PMID38667506
PMCPMC11052511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.