Evidence map›Paper›PMID 38667271›Full record

ArticleCells2024

Protecting Orthopaedic Implants from Infection: Antimicrobial Peptide Mel4 Is Non-Toxic to Bone Cells and Reduces Bacterial Colonisation When Bound to Plasma Ion-Implanted 3D-Printed PAEK Polymers.

Hedi Verena Kruse, Sudip Chakraborty, Renxun Chen, Naresh Kumar, Muhammad Yasir, William T Lewin, Natalka Suchowerska, Mark D P Willcox, David R McKenzie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hedi Verena KruseArto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Missenden Road, Camperdown, Sydney, NSW 2050, Australia.ORCID 0000-0002-6662-7549
Sudip ChakrabortySchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Renxun ChenSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-0828-9980
Naresh KumarSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-0951-9621
Muhammad YasirSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
William T LewinArto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Missenden Road, Camperdown, Sydney, NSW 2050, Australia.ORCID 0000-0003-1691-6294
Natalka SuchowerskaSchool of Physics, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-4515-7370
Mark D P WillcoxSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-3842-7563
David R McKenzieArto Hardy Family Biomedical Innovation Hub, Chris O'Brien Lifehouse, Missenden Road, Camperdown, Sydney, NSW 2050, Australia.
UNSW Sydney · AUThe University of Sydney · AU

Funding

Arto Hardy Family n/aAustralian Government n/aIan Potter Foundation n/aNational Health and Medical research Council of Australia APP1183597
6 · The paper itself

Abstract

Even with the best infection control protocols in place, the risk of a hospital-acquired infection of the surface of an implanted device remains significant. A bacterial biofilm can form and has the potential to escape the host immune system and develop resistance to conventional antibiotics, ultimately causing the implant to fail, seriously impacting patient well-being. Here, we demonstrate a 4 log reduction in the infection rate by the common pathogen

Indexed as

Antimicrobial PeptidesBenzophenonesPolymersPrinting, Three-DimensionalProstheses and ImplantsStaphylococcus aureusBiofilmsBone and BonesHumansKetonesOrthopedicsOsteoblastsPolyethylene GlycolsSurface PropertiesAntimicrobial PeptidesBenzophenonesKetonespolyetheretherketonePolyethylene GlycolsPolymers3D printingantimicrobial peptidebiofilmfilament deposition modellinginfection preventionorthopaedic implantplasma immersion ion implantationpolyether ether ketonepolyether ketoneselective laser sintering

Identifiers

PMID38667271
PMCPMC11049013
OpenAlexW4394604572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.