Evidence map›Paper›PMID 38666976›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities.

Attilio Di Maio, Hamza Olleik, Elise Courvoisier-Dezord, Sophie Guillier, Fabienne Neulat-Ripoll, Romain Haudecoeur, Jean-Michel Bolla, Magali Casanova, Jean-François Cavalier, Stéphane Canaan and 7 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Attilio Di MaioAix Marseille University, University Avignon, CNRS, IRD, IMBE, 13013 Marseille, France.ORCID 0009-0003-3663-4443
Hamza OlleikAix Marseille University, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.ORCID 0000-0002-3995-2207
Elise Courvoisier-DezordAix Marseille University, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.ORCID 0000-0002-4256-3528
Sophie GuillierAix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France.
Fabienne Neulat-RipollAix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France.
Romain HaudecoeurUniversity Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.ORCID 0000-0002-6271-4717
Jean-Michel BollaAix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France.ORCID 0000-0003-3892-4340
Magali CasanovaAix-Marseille University, CNRS, LISM UMR7255, IMM FR3479, 13009 Marseille, France.ORCID 0000-0002-1439-0762
Jean-François CavalierAix-Marseille University, CNRS, LISM UMR7255, IMM FR3479, 13009 Marseille, France.ORCID 0000-0003-0864-8314
Stéphane CanaanAix-Marseille University, CNRS, LISM UMR7255, IMM FR3479, 13009 Marseille, France.ORCID 0000-0001-7478-300X
Valérie PiqueAix Marseille University, University Avignon, CNRS, IRD, IMBE, 13013 Marseille, France.ORCID 0000-0001-8740-8495
Yolande CharmassonAix Marseille University, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.
Elias BaydounDepartment of Biology, American University of Beirut, Beirut 1107, Lebanon.
Akram HijaziPlateforme de Recherche et D'analyse en Sciences de L'environnement (EDST-PRASE), Beirut 1107, Lebanon.ORCID 0000-0003-4984-8531
Josette PerrierAix Marseille University, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.
Marc MarescaAix Marseille University, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.ORCID 0000-0002-3585-4765
Maxime RobinAix Marseille University, University Avignon, CNRS, IRD, IMBE, 13013 Marseille, France.ORCID 0000-0001-9914-786X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of new and effective antimicrobial compounds is urgent due to the emergence of resistant bacteria. Natural plant flavonoids are known to be effective molecules, but their activity and selectivity have to be increased. Based on previous aurone potency, we designed new aurone derivatives bearing acetamido and amino groups at the position 5 of the A ring and managing various monosubstitutions at the B ring. A series of 31 new aurone derivatives were first evaluated for their antimicrobial activity with five derivatives being the most active (compounds

Indexed as

anti-bacterial agentsauronecytotoxicity testsstructure-activity relationship

Identifiers

PMID38666976
PMCPMC11047580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.