Evidence map›Paper›PMID 38666967›Full record

ArticleAntibiotics (Basel, Switzerland)2024

A New 4-Thiazolidinone Derivative (Les-6490) as a Gut Microbiota Modulator: Antimicrobial and Prebiotic Perspectives.

Yulian Konechnyi, Tetyana Rumynska, Ihor Yushyn, Serhii Holota, Vira Turkina, Mariana Ryviuk Rydel, Alicja Sękowska, Yuriy Salyha, Olena Korniychuk, Roman Lesyk

Registry-linked trialAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06508398 (Species Spectrum and Biological Properties of Bacterial and Fungal Causative Agents of Health-care-associated Infections and in Vitro Study of Antimicrobial Activity Against Them Using 4-thiazolidinone Derivatives.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06508398 completednot on this map

Species Spectrum and Biological Properties of Bacterial and Fungal Causative Agents of Health-care-associated Infections and in Vitro Study of Antimicrobial Activity Against Them Using 4-thiazolidinone Derivatives.

Typeobservational_patient_registrySponsorDanylo Halytsky Lviv National Medical UniversityRan2017 to 2024Enrolled250ConditionsNosocomial InfectionArmsMicrobiological Diagnostic Testing
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yulian KonechnyiDepartment of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.ORCID 0000-0003-4789-1675
Tetyana RumynskaDepartment of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.ORCID 0000-0002-0669-5865
Ihor YushynDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.ORCID 0000-0001-7625-4531
Serhii HolotaDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.ORCID 0000-0002-9892-437X
Vira TurkinaResearch Institute of Epidemiology and Hygiene, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.ORCID 0000-0002-0660-8485
Mariana Ryviuk RydelDepartment of Intellectual Property, Information and Corporate Law, Ivan Franko National University of Lviv, 1 Universytetska St., 79000 Lviv, Ukraine.
Alicja SękowskaMicrobiology Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 9 Maria Skłodowska-Curie St., 85-094 Bydgoszcz, Poland.ORCID 0000-0001-6380-3968
Yuriy SalyhaInstitute of Animal Biology NAAS, Vasylya Stusa St., 38, 79034 Lviv, Ukraine.
Olena KorniychukDepartment of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
Roman LesykDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.ORCID 0000-0002-3322-0080

Funding

Ministry of Health of Ukraine 0121U100690, 0120U102460, 0123U100153National Research Foundation of Ukraine 2020.02/0035
6 · The paper itself

Abstract

A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound was screened for its antimicrobial activity against some pathogenic bacteria and fungi and showed activity against

Indexed as

4-thiazolidinonesanti-inflammatory activityantimicrobial activitygut microbiotametagenomic sequencingrats

Identifiers

PMID38666967
PMCPMC11047727

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.