ArticleEuropean journal of neurology2024
Symptom-based staging for logopenic variant primary progressive aphasia.
Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Atypical Alzheimer disease: a multi-axis framework toward defining heterogeneity.Nature reviews. Neurology · 2026Review
- Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.European journal of neurology · 2026Article
- Multidimensional cognitive deficit in logopenic variant primary progressive aphasia: a case report.Journal of medical case reports · 2026Article
- Staging Language-Led Neurodegenerative Diseases in a Language-Based World: The Challenge of the PPA-Squared Scale.European journal of neurology · 2026Article
- 'I Am No Longer Anxious When I Speak': Experiences of People with Primary Progressive Aphasia Taking Part in a Biographic-Narrative Therapy (Brain sciences · 2026Article
- Applicability and Correlates of a Symptom-Led Staging System for Primary Progressive Aphasia.European journal of neurology · 2025Article
- Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Article
- Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.Alzheimer's research & therapy · 2025Article
- Picture Description and Functional Communication Rating Correlates in Variants of Primary Progressive Aphasia.Aphasiology · 2025Article
- Data-driven neuroanatomical subtypes of primary progressive aphasia.Brain : a journal of neurology · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Decline in activities of daily living in the rarer dementias.General psychiatry · 2025Review
- Comprehension of acoustically degraded emotional prosody in Alzheimer's disease and primary progressive aphasia.Scientific reports · 2024Article
- Primary Progressive Aphasia in Italian and English: A Cross-Linguistic Cohort Study.Neurology · 2024Observational
- Symptom-based staging for logopenic variant primary progressive aphasia.European journal of neurology · 2024Article
- 'It Is of Course About Being Human Together': Co-Development of a Primary Progressive Aphasia Awareness Campaign to Enhance Understanding of Speech and Language Therapy.International journal of language & communication disordersArticle
Corrections and comments
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Authors and funding
26 authors.
Funding
Abstract
background and purposeLogopenic variant primary progressive aphasia (lvPPA) is a major variant presentation of Alzheimer's disease (AD) that signals the importance of communication dysfunction across AD phenotypes. A clinical staging system is lacking for the evolution of AD-associated communication difficulties that could guide diagnosis and care planning. Our aim was to create a symptom-based staging scheme for lvPPA, identifying functional milestones relevant to the broader AD spectrum.
methodsAn international lvPPA caregiver cohort was surveyed on symptom development under an 'exploratory' survey (34 UK caregivers). Feedback from this survey informed the development of a 'consolidation' survey (27 UK, 10 Australian caregivers) in which caregivers were presented with six provisional clinical stages and feedback was analysed using a mixed-methods approach.
resultsSix clinical stages were endorsed. Early symptoms included word-finding difficulty, with loss of message comprehension and speech intelligibility signalling later-stage progression. Additionally, problems with hearing in noise, memory and route-finding were prominent early non-verbal symptoms. 'Milestone' symptoms were identified that anticipate daily-life functional transitions and care needs.
conclusionsThis work introduces a new symptom-based staging scheme for lvPPA, and highlights milestone symptoms that could inform future clinical scales for anticipating and managing communication dysfunction across the AD spectrum.
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