Evidence map›Paper›PMID 38666377›Full record

ReviewNatural product reports2024

Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties.

Kyra R Dvorak, Jetze J Tepe

Abstract readReview
In one paragraph

Review in Natural product reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Bisindole Compounds-Synthesis and Medicinal Properties.Antibiotics (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kyra R DvorakMichigan State University, USA. dvorakky@msu.edu.
Jetze J TepeUniversity of Virginia, USA.ORCID 0000-0001-5467-5589

Funding

Small molecule induced proteolytic destruction of intrinsically disordered proteinsR01AG066223 · NIA · MICHIGAN STATE UNIVERSITY · PI TEPE, JETZE J. · 2019 to 2022
$1.7M
Overcoming proteasome impairment with small moleculesR21AG076994 · NIA · UNIVERSITY OF VIRGINIA · PI TEPE, JETZE J. · 2022 to 2022
$389k
NIA NIH HHS R01 AG066223NIA NIH HHS R21 AG076994
6 · The paper itself

Abstract

The past several years have seen an increase in the discovery and isolation of natural products of the indole alkaloid class. Bis- and tris-indole alkaloids are classes of natural products that have been shown to display diverse, potent biological activities. Of particular interest are bis- and tris-indole alkaloids containing N-heterocyclic linker moieties. It has been reported that more than 85% of biologically active compounds contain one or more heterocyclic moieties; of these, N-heterocycles have been identified as the most prevalent. The goal of this review is to provide a detailed overview of the recent advances in isolation and total synthesis of bis- and tris-indole alkaloids that contain N-heterocyclic linker moieties. The known biological activities of these natural products will also be discussed.

Indexed as

Biological ProductsHeterocyclic CompoundsIndole AlkaloidsMolecular StructureBiological ProductsHeterocyclic CompoundsIndole Alkaloids

Identifiers

PMID38666377
PMCPMC11323739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.