ArticlePsychoradiology2023
Sex differences of brain cortical structure in major depressive disorder.
Article in Psychoradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Abnormal Dynamic Functional Connectivity Within the Fronto-Limbic Network Mediates the Association Between Depressive Symptoms and Non-Suicidal Self-Injury in Adolescents.CNS neuroscience & therapeutics · 2026Article
- Sex differences in brain activity and connectivity in late-life depression.Psychoradiology · 2026Article
- Age- and sex-related glymphatic differences and hemispheric asymmetry in healthy adults at 7.0T magnetic resonance imaging.Psychoradiology · 2026Article
- Anxiety symptoms as a hub-mediation nexus in suicidal ideation among depressed patients.BMC psychiatry · 2025Article
- Mechanisms Underlying Treatment-Resistant Depression: Exploring Sex-Based Biological Differences.Journal of neurochemistry · 2025Review
- Depletion Effects Reduce the Preference for Distraction (but Not Reappraisal) During Emotion Regulation.PsyCh journal · 2025Article
- Sex-specific habenular dysconnectivity in patients with late-life depression.Translational psychiatry · 2025Article
- Exploring Gender Differences in the Relationship Between Thyroid Function and Aggressive and Impulsive Behaviors in Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Research Progress on Neural Processing of Hand and Forearm Tactile Sensation: A Review Based on fMRI Research.Neuropsychiatric disease and treatment · 2025Review
- Sex Differences in Cortical Structural Alterations in Major Depressive Disorder With Suicidal Ideation.Depression and anxiety · 2025Article
- Focus on the sex-specific neural markers in the discrimination of various degrees of depression.Psychoradiology · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Major depressive disorder (MDD) has different clinical presentations in males and females. However, the neuroanatomical mechanisms underlying these sex differences are not fully understood. Objective: The purpose of present study was to explore the sex differences in brain cortical thickness (CT) and surface area (SA) of MDD and the relationship between these differences and clinical manifestations in different gender. Methods: High-resolution T1-weighted images were acquired from 61 patients with MDD and 61 healthy controls (36 females and 25 males, both). The sex differences in CT and SA were obtained using the FreeSurfer software and compared between every two groups by Results: In male patients with MDD, the CT of the right precentral was thinner compared to female patients, although this did not survive Bonferroni correction. The SA of several regions, including right superior frontal, medial orbitofrontal gyrus, inferior frontal gyrus triangle, superior temporal, middle temporal, lateral occipital gyrus, and inferior parietal lobule in female patients with MDD was smaller than that in male patients ( Conclusion: The current study provides evidence of sex differences in CT and SA in patients with MDD, which may improve our understanding of the sex-specific neuroanatomical changes in the development of MDD.
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