ArticlePsychoradiology2023
The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit.
Article in Psychoradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
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- Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.The journal of headache and pain · 2025Article
- Striatal functional connectivity associated with Sahaja Yoga meditation.Scientific reports · 2025Article
- Enhanced disgust generalization in obsessive-compulsive disorder is related to insula and putamen hyperactivity.Psychological medicine · 2025Article
- From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025Review
- A surface-based cross-sectional fMRI study on brain function differences between comorbid mild or moderate depression and insomnia.Frontiers in neuroscience · 2025Article
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- Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype.Translational psychiatry · 2024Article
- Causal mechanisms of individual differences in hemispheric lateralization of the face perception network: A DCM-PEB approach.Imaging neuroscience (Cambridge, Mass.)Article
- Transcutaneous auricular vagus nerve stimulation enhanced emotional inhibitory control via increasing intrinsic prefrontal couplings.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal models. However, the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains controversial. Objective: The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors (i.e. sex) and behavioral performance. Methods: Here, we capitalize on the recent progress in robust and biologically plausible directed causal modeling (DCM-PEB) and a large response inhibition dataset ( Results: The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and rThal. Direct comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and rThal. In addition, sex and performance influenced the functional architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation, while better inhibitory performance was associated with stronger rThal to rIFG communication. Furthermore, control analyses did not reveal a similar key communication in a left lateralized model. Conclusions: Together, these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.
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