ArticlePsychoradiology2022
Linked brain connectivity patterns with psychopathological and cognitive phenotypes in drug-naïve first-episode schizophrenia.
Article in Psychoradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Neuroanatomical and transcriptomic correlates of attention in schizophrenia.Schizophrenia research. Cognition · 2026Article
- Contrastive Brain Network Learning via Hierarchical Signed Graph Pooling Model.IEEE transactions on neural networks and learning systems · 2024Article
- Brain network functional connectivity changes in long illness duration chronic schizophrenia.Frontiers in psychiatry · 2024Article
- Imaging Transcriptomics of the Brain for Schizophrenia.Alpha psychiatry · 2024Review
- Transcriptomics and magnetic resonance imaging in major psychiatric disorders.Frontiers in psychiatry · 2023Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions. Different brain connection abnormalities were found to be correlated with various clinical manifestations, but whether a common deficit in functional connectivity (FC) in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains elusive. Objective: To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations. Methods: A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors. A principal component analysis was performed on the clinical ratings of symptom and cognition. Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients. Results: Using the principal component analysis, the first principal component (PC1) explained 37% of the total variance of seven clinical features. The ratings of GAF and BACS contributed negatively to PC1, while those of PANSS, HAMD, and HAMA contributed positively. The FCs positively correlated with PC1 mainly included connections related to the insula, precuneus gyrus, and some frontal brain regions. FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions. Conclusion: In conclusion, we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-naïve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex, which may represent a core deficit of brain FC in patients with schizophrenia.
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