Evidence map›Paper›PMID 38665964›Full record

ArticleBrain communications2024

Abnormal gamma phase-amplitude coupling in the parahippocampal cortex is associated with network hyperexcitability in Alzheimer's disease.

Pooja Prabhu, Hirofumi Morise, Kiwamu Kudo, Alexander Beagle, Danielle Mizuiri, Faatimah Syed, Karunakar A Kotegar, Anne Findlay, Bruce L Miller, Joel H Kramer and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

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  9. Review
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  13. Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Pooja PrabhuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.
Hirofumi MoriseDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.
Kiwamu KudoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-5732-7229
Alexander BeagleMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Danielle MizuiriDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.
Faatimah SyedMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Karunakar A KotegarDepartment of Data science and Computer Applications, Manipal Institute of Technology, Manipal 576104, India.
Anne FindlayDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Katherine P RankinMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Paul A GarciaEpilepsy Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Heidi E KirschDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.
Keith VosselMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.
Kamalini G RanasingheMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-4217-8785
University of California, San Francisco · USManipal Academy of Higher Education · INUniversity of California, Los Angeles · US

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Network Modelling of Multimodal Dynamics in Alzheimer’s Disease and DementiaRF1AG062196 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2019 to 2019
$3.0M
Neurophysiological Assessments of Network Dysfunction in Alzheimer's DiseaseK08AG058749 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANASINGHE, KAMALINI GAYATHREE · 2019 to 2023
$859k
Mechanisms and Treatment of Network Dysfunction in Alzheimer's DiseaseK23AG038357 · NIA · J. DAVID GLADSTONE INSTITUTES · PI VOSSEL, KEITH ALAN · 2011 to 2015
$764k
Multimodal imaging measures to assess synaptic dysfunction in Alzheimer's diseaseR21AG077498 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANASINGHE, KAMALINI GAYATHREE · 2022 to 2022
$484k
NIA NIH HHS K08 AG058749NIA NIH HHS K23 AG038357NIA NIH HHS P50 AG023501NIA NIH HHS R21 AG077498NIA NIH HHS RF1 AG062196NIDCD NIH HHS R01 DC017091NINDS NIH HHS R01 NS100440
6 · The paper itself

Abstract

While animal models of Alzheimer's disease (AD) have shown altered gamma oscillations (∼40 Hz) in local neural circuits, the low signal-to-noise ratio of gamma in the resting human brain precludes its quantification via conventional spectral estimates. Phase-amplitude coupling (PAC) indicating the dynamic integration between the gamma amplitude and the phase of low-frequency (4-12 Hz) oscillations is a useful alternative to capture local gamma activity. In addition, PAC is also an index of neuronal excitability as the phase of low-frequency oscillations that modulate gamma amplitude, effectively regulates the excitability of local neuronal firing. In this study, we sought to examine the local neuronal activity and excitability using gamma PAC, within brain regions vulnerable to early AD pathophysiology-entorhinal cortex and parahippocampus, in a clinical population of patients with AD and age-matched controls. Our clinical cohorts consisted of a well-characterized cohort of AD patients (

Indexed as

Alzheimer’s diseasegamma oscillationsmagnetoencephalographynetwork hyperexcitabilityphase-amplitude coupling

Identifiers

PMID38665964
PMCPMC11043655
OpenAlexW4394594759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.