Evidence map›Paper›PMID 38665923›Full record

ArticleFrontiers in immunology2024

The bone marrow endothelial progenitor cell response to septic infection.

Xin Shi, Kevin J Simms, Thomas J Ewing, Yuan-Ping Lin, Yi-Ling Chen, John N Melvan, Robert W Siggins, Ping Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Xin ShiDepartment of Integrative Medical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, United States.
Kevin J SimmsDepartment of Integrative Medical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, United States.
Thomas J EwingWest Clinical Laboratory, Lakeland Regional Health Medical Center, Lakeland, FL, United States.
Yuan-Ping Lin3R Life Sciences Ltd., Kaohsiung City, Taiwan.
Yi-Ling ChenInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.
John N MelvanMemorial Cardiac and Vascular Institute, Memorial Healthcare System, Hollywood, FL, United States.
Robert W SigginsDepartment of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Ping ZhangDepartment of Integrative Medical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, United States.
Northeast Ohio Medical University · USAdvanced Semiconductor Engineering (Taiwan) · TWKaohsiung Chang Gung Memorial Hospital · TWLouisiana State University Health Sciences Center New Orleans · USMemorial Healthcare System · USRegional Health · US

Funding

Alcohol, Septicemia and the LKS Cell ResponseR01AA019676 · NIAAA · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2010 to 2014
$1.7M
Alcohol, hedgehog signal, and HSC dysfunction in host defense against septicemiaR01AA022816 · NIAAA · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2014 to 2018
$1.7M
Sca-1 signaling, EPC, and the inflammatory response to septic infectionR01GM132449 · NIGMS · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2019 to 2022
$1.4M
NIAAA NIH HHS R01 AA019676NIAAA NIH HHS R01 AA022816NIGMS NIH HHS R01 GM132449
6 · The paper itself

Abstract

Early increase in the level of endothelial progenitor cells (EPCs) in the systemic circulation occurs in patients with septic infection/sepsis. The significance and underlying mechanisms of this response remain unclear. This study investigated the bone marrow EPC response in adult mice with septic infection induced by intravenous injection (i.v.) of

Indexed as

Endothelial Progenitor CellsMembrane ProteinsSepsisAnimalsAntigens, LyBone Marrow CellsCells, CulturedEscherichia coliEscherichia coli InfectionsMaleMiceMice, Inbred C57BLMice, KnockoutVascular Endothelial Growth Factor AAntigens, LyLy6a protein, mouseMembrane ProteinsVascular Endothelial Growth Factor Abone marrowcell signalingendothelial progenitor cellshost defense responsemicrovascular injuryseptic infection

Identifiers

PMID38665923
PMCPMC11044677
OpenAlexW4393946886

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.