Evidence map›Paper›PMID 38665908›Full record

ArticleFrontiers in immunology2024

Molecular dissection of an immunodominant epitope in K

Ivan Talucci, Friederike A Arlt, Kai O Kreissner, Mahoor Nasouti, Anna-Lena Wiessler, Ramona Miske, Swantje Mindorf, Inga Dettmann, Mehrnaz Moniri, Markus Bayer and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Ivan Talucci *Rudolf Virchow Center for Integrative and Translational Bioimaging; University of Würzburg, Würzburg, Germany.
Friederike A Arlt *Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, Berlin, Germany.
Kai O KreissnerRudolf Virchow Center for Integrative and Translational Bioimaging; University of Würzburg, Würzburg, Germany.
Mahoor NasoutiRudolf Virchow Center for Integrative and Translational Bioimaging; University of Würzburg, Würzburg, Germany.
Anna-Lena WiesslerInstitute for Clinical Neurobiology, University of Wuerzburg, Würzburg, Germany.
Ramona MiskeInstitute for Experimental Immunology, affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
Swantje MindorfInstitute for Experimental Immunology, affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
Inga DettmannInstitute for Experimental Immunology, affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
Mehrnaz MoniriRudolf Virchow Center for Integrative and Translational Bioimaging; University of Würzburg, Würzburg, Germany.
Markus BayerRudolf Virchow Center for Integrative and Translational Bioimaging; University of Würzburg, Würzburg, Germany.
Peter Broegger ChristensenDepartment of Neurology, Aalborg University Hospital, Aalborg, Denmark.
Ilya AyzenbergDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
Andrea KraftDepartment of Neurology, Hospital Martha-Maria, Halle, Germany.
Matthias EndresGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Lars KomorowskiInstitute for Experimental Immunology, affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
Carmen VillmannInstitute for Clinical Neurobiology, University of Wuerzburg, Würzburg, Germany.
Kathrin DopplerDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Harald PrüssDepartment of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, Berlin, Germany.
Hans M MaricRudolf Virchow Center for Integrative and Translational Bioimaging; University of Würzburg, Würzburg, Germany.
University of Würzburg · DEEuroimmun Medizinische Labordiagnostika (Germany) · DECharité - Universitätsmedizin Berlin · DEUniversitätsklinikum Würzburg · DEAalborg University Hospital · DKFreie Universität Berlin · DEGerman Centre for Cardiovascular Research · DEMartha-Maria Hospital · DESt. Josef-Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Subgroups of autoantibodies directed against voltage-gated potassium channel (K Methods: Binding epitopes were studied in sera (n = 36) and cerebrospinal fluid (CSF) (n = 12) from a patient cohort positive for K Results: 83% of the patients (30/36) within the studied cohort shared one out of the two major binding epitopes with K Discussion: Systematic mapping revealed two shared autoimmune responses, with one dominant K

Indexed as

AutoantibodiesAutoimmunityImmunodominant EpitopesKv1.2 Potassium ChannelAdultAnimalsAutoantigensEpitope MappingFemaleHumansMaleMiddle AgedAutoantibodiesAutoantigensImmunodominant EpitopesKv1.2 Potassium Channelautoantibodiesautoimmune encephalitiscriticaldementiaepitope mappingimmunodominant antigenKCNA2Kv channel

Identifiers

PMID38665908
PMCPMC11043588
OpenAlexW4394724290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.