Evidence map›Paper›PMID 38665828›Full record

ArticleRSC medicinal chemistry2024

Discovery of novel positive allosteric modulators targeting GluN1/2A NMDARs as anti-stroke therapeutic agents.

Hongyu Zhu, Xin Chen, Lu Zhang, Xuequan Liu, Ji Chen, Han-Ting Zhang, Mingxin Dong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hongyu ZhuSchool of Pharmacy, Qingdao University Qingdao Shandong 266021 People's Republic of China htzhang@qdu.edu.cn mxdong64@qdu.edu.cn.ORCID https://orcid.org/0000-0002-2309-1844
Xin ChenSchool of Pharmacy, Qingdao University Qingdao Shandong 266021 People's Republic of China htzhang@qdu.edu.cn mxdong64@qdu.edu.cn.
Lu ZhangDepartment of Clinical Laboratory, Qingdao Women's and Children's Hospital Qingdao 266034 Shandong Province China.
Xuequan LiuSchool of Pharmacy, Qingdao University Qingdao Shandong 266021 People's Republic of China htzhang@qdu.edu.cn mxdong64@qdu.edu.cn.
Ji ChenSchool of Pharmacy, Qingdao University Qingdao Shandong 266021 People's Republic of China htzhang@qdu.edu.cn mxdong64@qdu.edu.cn.
Han-Ting ZhangSchool of Pharmacy, Qingdao University Qingdao Shandong 266021 People's Republic of China htzhang@qdu.edu.cn mxdong64@qdu.edu.cn.
Mingxin DongSchool of Pharmacy, Qingdao University Qingdao Shandong 266021 People's Republic of China htzhang@qdu.edu.cn mxdong64@qdu.edu.cn.ORCID https://orcid.org/0000-0001-8623-0146
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excitotoxicity due to excessive activation of NMDARs is one of the main mechanisms of neuronal death during ischemic stroke. Previous studies have suggested that activation of either synaptic or extrasynaptic GluN2B-containing NMDARs results in neuronal damage, whereas activation of GluN2A-containing NMDARs promotes neuronal survival against ischemic insults. This study applied a systematic

Identifiers

PMID38665828
PMCPMC11042165
OpenAlexW4390574306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.