Evidence map›Paper›PMID 38665774›Full record

ArticlebioRxiv : the preprint server for biology2024

Quantitative tests of albendazole resistance in beta-tubulin mutants.

J B Collins, Skyler A Stone, Emily J Koury, Anna G Paredes, Fiona Shao, Crystal Lovato, Michael Chen, Richelle Shi, Anwyn Y Li, Isa Candal and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

J B CollinsDepartment of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0003-0808-5216
Skyler A StoneDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Emily J KouryDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Anna G ParedesDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Fiona ShaoDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Crystal LovatoDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Michael ChenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Richelle ShiDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Anwyn Y LiDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Isa CandalDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Khadija Al MoutaaDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Nicolas MoyaDepartment of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Erik C AndersenDepartment of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0003-0229-9651
Northwestern University · USJohns Hopkins University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Discovery of Novel Benzimidazole Resistance MechanismsR01AI153088 · NIAID · NORTHWESTERN UNIVERSITY · PI Erik Christian Andersen, James Solomon Fraser · 2020 to 2026
$4.3M
NIAID NIH HHS R01 AI153088NIH HHS P40 OD010440
6 · The paper itself

Abstract

Benzimidazole (BZ) anthelmintics are among the most important treatments for parasitic nematode infections in the developing world. Widespread BZ resistance in veterinary parasites and emerging resistance in human parasites raise major concerns for the continued use of BZs. Knowledge of the mechanisms of resistance is necessary to make informed treatment decisions and circumvent resistance. Benzimidazole resistance has traditionally been associated with mutations and natural variants in the

Indexed as

anthelmintic resistancebenzimidazolebeta-tubulinC. elegans

Identifiers

PMID38665774
PMCPMC11044196
OpenAlexW4394790321

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.