Evidence map›Paper›PMID 38665576›Full record

ArticleHeliyon2024

An integrated radiology-pathology machine learning classifier for outcome prediction following radical prostatectomy: Preliminary findings.

Amogh Hiremath, Germán Corredor, Lin Li, Patrick Leo, Cristina Magi-Galluzzi, Robin Elliott, Andrei Purysko, Rakesh Shiradkar, Anant Madabhushi

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Amogh HiremathPicture Health, Cleveland, OH, USA.
Germán CorredorDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Lin LiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Patrick LeoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Cristina Magi-GalluzziPathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Robin ElliottDepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Andrei PuryskoDepartment of Radiology and Nuclear Medicine, Cleveland Clinic, Cleveland, OH, USA.
Rakesh ShiradkarDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Anant MadabhushiDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Georgia Institute of Technology · USCase Western Reserve University · USCleveland Clinic · USUniversity Hospitals of Cleveland · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To evaluate the added benefit of integrating features from pre-treatment MRI (radiomics) and digitized post-surgical pathology slides (pathomics) in prostate cancer (PCa) patients for prognosticating outcomes post radical-prostatectomy (RP) including a) rising prostate specific antigen (PSA), and b) extraprostatic-extension (EPE). Methods: Multi-institutional data (N = 58) of PCa patients who underwent pre-treatment 3-T MRI prior to RP were included in this retrospective study. Radiomic and pathomic features were extracted from PCa regions on MRI and RP specimens delineated by expert clinicians. On training set (D1, N = 44), Cox Proportional-Hazards models M Results: Patients had median follow-up of 34 months. M Conclusions: Results from this preliminary study suggest that a combination of radiomic and pathomic features can better predict post-surgical outcomes (rising PSA and EPE) compared to either of them individually as well as extant prognostic nomogram (CAPRA).

Indexed as

HistopathologyMachine learningMRIPrognosisProstate cancer

Identifiers

PMID38665576
PMCPMC11044050
OpenAlexW4394824011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.