ArticleBJC reports2023
Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease.
Article in BJC reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Genome, transcriptome and methylome-wide association studies have identified single-nucleotide polymorphisms (SNPs) or genes at 258 loci associated with colorectal cancer (CRC) risk. We studied the relationship between these and patient outcome. Methods: We studied 1926 unrelated patients with advanced CRC from COIN and COIN-B. Of 205 CRC-risk SNPs, 19 were directly genotyped and 162 were imputed, and of 53 risk genes, 52 were tested. An additive Cox model for overall survival was adjusted for known prognostic factors. For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of Results: Eleven SNPs or genes were nominally associated with survival under an additive model. Only rs117079142 mapping to Conclusion: rs117079142 and rs9924886 may represent potential prognostic biomarkers for CRC.
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