ArticleJournal of biomedical optics2024
Margin assessment during breast conserving surgery using diffuse reflectance spectroscopy.
Article in Journal of biomedical optics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Margin status after breast-conserving surgery for breast cancer in the Netherlands from 2009 to 2022.BJS open · 2026Article
- Detection of margin positivity in breast cancer using fluorescence and diffuse reflectance imaging.Journal of Taibah University Medical Sciences · 2026Article
- Time-Resolved Fluorescence and Diffuse Reflectance (TRF-DR) Spectroscopy for Heterogeneous Breast Tissue Classification and Tumor Margin Assessment.Journal of biophotonics · 2026Article
- Diffuse reflectance spectroscopy for enhanced diagnostic precision in breast cancer.Journal of translational medicine · 2025Article
- Imaging Through Scattering Tissue Based on NIR Multispectral Image Fusion Technique.Sensors (Basel, Switzerland) · 2025Article
- Toward real-time margin assessment in breast-conserving surgery with hyperspectral imaging.Scientific reports · 2025Article
- Study of Minor Chromophores in Biological Tissues by Diffuse Optical Spectroscopy (Review).Sovremennye tekhnologii v meditsine · 2025Review
- Feasibility of Diffuse Reflection Spectroscopy for Intraoperative Margin Assessment During Prostatectomy.European urology open science · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: During breast-conserving surgeries, it is essential to evaluate the resection margins (edges of breast specimen) to determine whether the tumor has been removed completely. In current surgical practice, there are no methods available to aid in accurate real-time margin evaluation. Aim: In this study, we investigated the diagnostic accuracy of diffuse reflectance spectroscopy (DRS) combined with tissue classification models in discriminating tumorous tissue from healthy tissue up to 2 mm in depth on the actual resection margin of Approach: We collected an extensive dataset of DRS measurements on Results: We achieved a Matthews correlation coefficient of 0.76, a sensitivity of 96.7% (95% CI 95.6% to 98.2%), a specificity of 90.6% (95% CI 86.3% to 97.9%) and an area under the curve of 0.98 by training the optimum model on a combination of Conclusions: DRS allows real-time margin assessment with a high sensitivity and specificity during breast-conserving surgeries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.