Evidence map›Paper›PMID 38665239›Full record

ArticleNpj viruses2023

Rhinovirus dynamics across different social structures.

Martha M Luka, James R Otieno, Everlyn Kamau, John Mwita Morobe, Nickson Murunga, Irene Adema, Joyce Uchi Nyiro, Peter M Macharia, Godfrey Bigogo, Nancy A Otieno and 7 more

Abstract read
In one paragraph

Article in Npj viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Martha M LukaEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
James R OtienoEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
Everlyn KamauEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
John Mwita MorobeEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
Nickson MurungaEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
Irene AdemaEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
Joyce Uchi NyiroEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
Peter M MachariaPopulation & Health Impact Surveillance Group, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.
Godfrey BigogoKEMRI-Centre for Global Health Research, Kisumu, Kenya.
Nancy A OtienoKEMRI-Centre for Global Health Research, Kisumu, Kenya.
Bryan O NyawandaKEMRI-Centre for Global Health Research, Kisumu, Kenya.
Maia A RabaaCoronavirus and Other Respiratory Viruses Division (CORVD), National Center for Immunization and Respiratory Diseases (NCIRD), U.S. Centers of Disease Control and Prevention (CDC), Atlanta, GA USA.
Gideon O EmukuleU.S. Centers of Disease Control and Prevention (CDC), Nairobi, Kenya.
Clayton OnyangoU.S. Centers of Disease Control and Prevention (CDC), Nairobi, Kenya.
Patrick K MunywokiEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
Charles N AgotiEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.
D James NokesEpidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.

Funding

Eastern Africa Network for Bioinformatics Training - (EANBiT)U2RTW010677 · FIC · INTERNATIONAL CENTRE OF INSECT PHYSIOLOG · PI MASIGA, DANIEL KANANI · 2017 to 2022
$1.2M
EPA EP-C-15-003FIC NIH HHS U2R TW010677Wellcome Trust
6 · The paper itself

Abstract

Rhinoviruses (RV), common human respiratory viruses, exhibit significant antigenic diversity, yet their dynamics across distinct social structures remain poorly understood. Our study delves into RV dynamics within Kenya by analysing VP4/2 sequences across four different social structures: households, a public primary school, outpatient clinics in the Kilifi Health and Demographics Surveillance System (HDSS), and countrywide hospital admissions and outpatients. The study revealed the greatest diversity of RV infections at the countrywide level (114 types), followed by the Kilifi HDSS (78 types), the school (47 types), and households (40 types), cumulatively representing >90% of all known RV types. Notably, RV diversity correlated directly with the size of the population under observation, and several RV type variants occasionally fuelled RV infection waves. Our findings highlight the critical role of social structures in shaping RV dynamics, information that can be leveraged to enhance public health strategies. Future research should incorporate whole-genome analysis to understand fine-scale evolution across various social structures.

Indexed as

EpidemiologyViral epidemiology

Identifiers

PMID38665239
PMCPMC11041716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.