Evidence map›Paper›PMID 38665207›Full record

ArticleiScience2024

The role of Testis-Specific Protein Y-encoded-Like 2 in kidney injury.

Mingxing Sui, Sijia Yan, Pei Zhang, Yuhong Li, Kewen Chen, Yanhua Li, Hanlan Lu, Yanfeng Li, Wenyu Zhao, Li Zeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mingxing SuiDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Sijia YanDepartment of Pathology, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pei ZhangDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yuhong LiDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Kewen ChenDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yanhua LiDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Hanlan LuDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yanfeng LiDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Wenyu ZhaoDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Li ZengDepartment of Organ Transplantation, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Second Military Medical University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Recent findings suggest that Testis-Specific Protein Y-encoded-Like 2 (TSPYL2) plays a fibrogenic role in diabetes-associated renal injury. However, the role of TSPYL2 in IRI-induced kidney damage is not entirely clear. In this study, we found that the expression of TSPYL2 was upregulated in a mouse model of AKI and in the hypoxia/reoxygenation (H/R) cell model. Knockdown of TSPYL2 attenuated kidney injury after IRI. More specifically, the knockdown of TSPYL2 or aminocarboxymuconate-semialdehyde decarboxylase (ACMSD) alleviated renal IRI-induced mitochondrial dysfunction and oxidative stress

Indexed as

CancerCancer systems biologyGenomic analysisGenomics

Identifiers

PMID38665207
PMCPMC11043847
OpenAlexW4393226686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.