Evidence map›Paper›PMID 38664791›Full record

ArticleBMC women's health2024

Prevalence of high-risk human papillomavirus infection among women with diabetes mellitus in Accra, Ghana.

Yacoba Atiase, Kofi Effah, Comfort Mawusi Wormenor, Ethel Tekpor, Esu Aku Catherine Morkli, Eunice Boafo, Ernest Yorke, Robert Aryee, Nana Owusu Mensah Essel, Stephen Danyo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yacoba AtiaseDepartment of Medicine and Therapeutics, University of Ghana Medical School, P. O. Box GP 4236, Accra, Ghana. yatiase@ug.edu.gh.
Kofi EffahCatholic Hospital, Battor, P. O. Box 2, Battor, Ghana.
Comfort Mawusi WormenorCatholic Hospital, Battor, P. O. Box 2, Battor, Ghana.
Ethel TekporCatholic Hospital, Battor, P. O. Box 2, Battor, Ghana.
Esu Aku Catherine MorkliCatholic Hospital, Battor, P. O. Box 2, Battor, Ghana.
Eunice BoafoDepartment of Medicine and Therapeutics, Korle-Bu Teaching Hospital, Korle-Bu, P. O. Box KB 77, Accra, Ghana.
Ernest YorkeDepartment of Medicine and Therapeutics, University of Ghana Medical School, P. O. Box GP 4236, Accra, Ghana.
Robert AryeeDepartment of Cardiology, University of Ghana Medical Center, P. O. Box LG 25, Accra, Ghana.
Nana Owusu Mensah EsselDepartment of Emergency Medicine, College of Health Sciences, Faculty of Medicine and Dentistry, University of Alberta, 730 University Terrace, Edmonton, AB, T6G 2T4, Canada.
Stephen DanyoCatholic Hospital, Battor, P. O. Box 2, Battor, Ghana.
Seyram KemaworCatholic Hospital, Battor, P. O. Box 2, Battor, Ghana.
Josephine AkpaluDepartment of Medicine and Therapeutics, University of Ghana Medical School, P. O. Box GP 4236, Accra, Ghana.
Catholic University College of Ghana · GHUniversity of Ghana · GHKorle Bu Teaching Hospital · GHUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is increasing evidence of a higher risk and poorer prognosis of cervical cancer among women with diabetes mellitus (DM) compared to the general population. These are mediated by higher susceptibility to persistent high-risk human papillomavirus (hr-HPV) infection due to dysfunctional clearance in an immunocompromised state. We aimed to determine the prevalence of hr-HPV infection and cervical lesions in a cohort of women with DM in Ghana. We further disaggregated the prevalence according to DM type and explored factors associated with hr-HPV infection.

methodsThis retrospective descriptive cross-sectional study assessed 198 women with DM who underwent cervical screening via concurrent hr-HPV DNA testing and visual inspection with acetic acid in an outpatient department of the National Diabetes Management and Research Centre in Korle-Bu Teaching Hospital, Accra from March to May 2022. Univariate and multivariable binary logistic regression were used to explore factors associated with hr-HPV positivity.

resultsAmong 198 women with DM (mean age, 60.2 ± 12.1 years), the overall hr-HPV prevalence rate was 21.7% (95% CI, 16.1-28.1), disaggregated as 1.5% (95% CI, 0.3-4.4) each for HPV16 and HPV18 and 20.7% (95% CI, 15.3-27.0) for other HPV genotype(s). Respective hr-HPV prevalence rates were 37.5% (95% CI, 15.2-64.6) for type 1 DM, 19.8% (95% CI, 13.9-26.7) for type 2 DM, and 25.0% (95% CI, 8.7-49.1) for unspecified/other DM types. Past use of the combined contraceptive pill independently increased the risk of hr-HPV infection by approximately three times (adjusted odds ratio [aOR] = 2.98; 95% CI, 1.03 - 8.64; p-value = 0.045), whereas each unit increase in FBG level increased the odds of hr-HPV infection by about 15% (aOR = 1.15; 95% CI, 1.02 - 1.30; p-value = 0.021).

conclusionOur study points to a high prevalence of hr-HPV among women with DM and highlights a need for glycemic control among them as this could contribute to lowering their odds of hr-HPV infection. The low overall rates of HPV vaccination and prior screening also indicate a need to build capacity and expand the scope of education and services offered to women with DM as regards cervical precancer screening.

Indexed as

Papillomavirus InfectionsUterine Cervical NeoplasmsAdultAgedCross-Sectional StudiesDiabetes MellitusFemaleGhanaHumansMiddle AgedPapillomaviridaePrevalenceRetrospective StudiesRisk FactorsCervical precancer screeningDiabetes mellitusHuman papillomavirus DNA testingHuman papillomavirus infectionVisual inspection with acetic acid

Identifiers

PMID38664791
PMCPMC11044360
OpenAlexW4395464089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.