ArticleAlzheimer's research & therapy2024
Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea.
Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Identifying risk factors of young-onset dementia and evaluating evidence hierarchy: a meta-analysis and umbrella review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Development of a mortality prediction nomogram for dementia patients using the MIMIC-IV database.Scientific reports · 2026Article
- Effects of Sarcopenia and Frailty on Cognitive Function, Brain Volume, and Dementia Risk: A Prospective Cohort Study Based on UK Biobank.Dementia and neurocognitive disorders · 2026Article
- Early-Onset Dementia Risk Escalates with Diabetes Duration: Insights from a Nationwide Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Risk factors for early-onset and late-onset dementia: a prospective cohort study.The lancet. Healthy longevity · 2026Article
- Survival and mortality rates in early onset dementia.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Osteoporosis and risk of dementia among older adults: a population‑based cohort study.Bone research · 2025Observational
- Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.Neuroepidemiology · 2025Article
- Job Loss and Early-onset Dementia Risk in Middle-aged Adults: A Longitudinal Study.Safety and health at work · 2025Article
- The influence of depression onset timing after gastrointestinal diseases on dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Toxocariasis as an Elderly Zoonosis: Seroprevalence, Neurocognitive Assessment, and Associated Risk Factors in Persons 50 Years and Older.Pathogens (Basel, Switzerland) · 2025Article
- Scoping review exploring the impact of hip fracture in older adults with cognitive impairment or dementia.BMJ open · 2025Article
- Modifiable risk factors for early- and late-onset dementia using the Korean national health insurance service database.The journal of prevention of Alzheimer's disease · 2025Article
- Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts.Frontiers in public health · 2025Article
- Trends in Global Burden of Alzheimer's Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990-2021.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundEarly-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ 65) exhibit distinct features. Understanding the risk factors for dementia development and mortality in EOD and LOD respectively is crucial for personalized care. While risk factors are known for LOD development and mortality, their impact on EOD remains unclear. We aimed to investigate how hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, and osteoporosis influence the development and mortality of EOD and LOD, respectively.
methodsUsing the Korean National Health Insurance Service (NHIS) database, we collected 546,709 dementia-free individuals and followed up for 11 years. In the two study groups, the Younger group (< 65 years old) and the Older group (≥ 65 years old), we applied Cox proportional hazard models to assess risk factors for development of EOD and LOD, respectively. Then, we assessed risk factors for mortality among EOD and LOD.
resultsDiabetes mellitus and osteoporosis increased the risk of EOD and LOD development. Hypertension increased the risk of EOD, while atrial fibrillation increased the risk of LOD. Conversely, hyperlipidemia exhibited a protective effect against LOD development. Additionally, diabetes mellitus increased mortality in EOD and LOD. Hypertension and atrial fibrillation increased mortality in LOD, while hyperlipidemia decreased mortality in EOD and LOD.
conclusionsRisk factors influencing dementia development and mortality differed in EOD and LOD. Targeted public health interventions addressing age-related risk factors may reduce dementia incidence and mortality.
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Registered trials
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