Evidence map›Paper›PMID 38664586›Full record

ArticleNature chemical biology2024

Minimizing higher-order aggregation maximizes iron mobilization by small molecules.

Andrew D Blake, Jianhua Chao, Anna M SantaMaria, Stella Ekaputri, Kelsie J Green, Samantha T Brown, Christopher K Rakowski, Eun-Kyung Choi, Luisa Aring, Peng-Jui Chen and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Andrew D BlakeDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-2672-1354
Jianhua ChaoAmbys Medicines, South San Francisco, CA, USA.
Anna M SantaMariaDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0001-8735-0721
Stella EkaputriDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kelsie J GreenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Samantha T BrownDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Christopher K RakowskiDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Eun-Kyung ChoiDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Luisa AringDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0437-4785
Peng-Jui ChenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-3594-0081
Nicholas M SneadAmbys Medicines, South San Francisco, CA, USA.
Douglas M MatjeAmbys Medicines, South San Francisco, CA, USA.
Tao GengAmbys Medicines, South San Francisco, CA, USA.
Angela OctavianiAmbys Medicines, South San Francisco, CA, USA.
Keith BaileyAlnylam Pharmaceuticals, Inc., Cambridge, MA, USA.
Stanley J HollenbachAmbys Medicines, South San Francisco, CA, USA.
Timothy M FanDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0003-2510-7050
Young-Ah SeoDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. youngseo@umich.edu.ORCID http://orcid.org/0000-0003-3884-0665
Martin D BurkeDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA. mdburke@illinois.edu.ORCID http://orcid.org/0000-0001-7963-7140
University of Illinois Urbana-Champaign · USUniversity of Michigan · USAlnylam Pharmaceuticals (United States) · US

Funding

Molecular Prosthetics and Lego ChemistryR35GM118185 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Martin D Burke · 2016 to 2026
$6.6M
Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Manganese in Inflammatory Bowel DiseaseR01DK123022 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Young Ah Seo · 2020 to 2026
$3.2M
Using a small molecule iron transporter to understand and treat FPN1 deficiencies in miceR01HL140526 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BURKE, MARTIN D, KIM, JONGHAN · 2018 to 2021
$2.8M
Exploring the Roles of Manganese in NeuronsR21NS112974 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEO, YOUNG AH · 2020 to 2020
$429k
An IC-ICP-MS for advanced speciation and metalomics analysisS10OD020118 · OD · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 2015 to 2015
$268k
NHLBI NIH HHS R01 HL140526NIDDK NIH HHS R01 DK123022NIGMS NIH HHS R35 GM118185NIGMS NIH HHS T32 GM070421NIH HHS S10 OD020118NINDS NIH HHS R21 NS112974U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL140526U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM118185U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32GM070421
6 · The paper itself

Abstract

The natural product hinokitiol mobilizes iron across lipid bilayers at low concentrations and restores hemoglobinization in iron transporter protein-deficient systems. But hinokitiol fails to similarly mobilize iron at higher concentrations, limiting its uses in chemical biology and medicine. Here we show that at higher concentrations, hinokitiol

Indexed as

IronAnimalsFerric CompoundsHumansLipid BilayersMiceMice, Inbred C57BLStructure-Activity RelationshipTropoloneFerric CompoundsIronLipid BilayersTropolone

Identifiers

PMID38664586
PMCPMC11831690
OpenAlexW4395454181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.