ArticleNature communications2024
BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 13 citations in OpenAlex.
- A comparative analysis of cardiac bridging Integrator 1 (cBIN1) levels in patients with heart failure and healthy controls: A prospective case-control study.Pakistan journal of medical sciences · 2026Article
- 14-3-3 proteins: Regulators of cardiac excitation-contraction coupling and stress responses.The Journal of physiology · 2026Review
- CaThe Journal of physiology · 2026Article
- Nanoscale CabioRxiv : the preprint server for biology · 2026Article
- A new Fight-or-Flight Pacemaker Mechanism via Ryanodine Receptor abundance and superclustering.PLoS computational biology · 2026Article
- Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease.Circulation research · 2026Article
- Local calcium dynamics and signalling in cardiomyocytes.Nature reviews. Cardiology · 2026Review
- Demonstration of beat-to-beat, on-demand ATP synthesis in ventricular myocytes reveals sex-specific mitochondrial and cytosolic dynamics.The Journal of physiology · 2026Article
- BIN1 gene replacement reverses BIN1-related centronuclear myopathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Early Stage Morphogenesis of Transverse Tubules in Rat Cardiomyocytes: The Role of pBIN1.Circulation research · 2025Article
- Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology.American journal of physiology. Heart and circulatory physiology · 2025Review
- BIN1 reduction amelioratesProceedings of the National Academy of Sciences of the United States of America · 2025Article
- 14-3-3 promotes sarcolemmal expression of cardiac CaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Channels, Transporters, and Receptors at Membrane Contact Sites.Contact (Thousand Oaks (Ventura County, Calif.))Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Maartje Westhoff *Department of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.
Silvia G Del Villar *Department of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.
Taylor L VoelkerDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.
Phung N ThaiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-7344-150X
Heather C SpoonerDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-0873-8021
Alexandre D CostaDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-8181-0096
Padmini SirishDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-9216-279X
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA, USA.
Eamonn J DicksonDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-8619-7630
Rose E DixonDepartment of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA. redickson@ucdavis.edu.ORCID http://orcid.org/0000-0003-0655-690X
University of California, Davis · USVA Northern California Health Care System · US
Funding
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6MFunctional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3MTraining Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1MTranslational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7MMolecular choreography of CaV1.2 channels in the aging myocardiumR01AG063796 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rose Ellen Dixon · 2019 to 2026
$3.1MLipid regulation of Cardiac Excitation-Contraction couplingR01HL159304 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIXON, ROSE ELLEN · 2022 to 2025
$2.4MTargeting the genotype to phenotype link in HCM as a therapeutic strategyR01HL152055 · NHLBI · STANFORD UNIVERSITY · PI MERCOLA, MARK · 2021 to 2024
$2.3MDecoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2MPredoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2MAlpha-Synuclein aberrantly modifies the nanoscale distribution and function of ion channels to promote neuronal cytotoxicityRF1NS131379 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES · 2023 to 2023
$1.7MLysosomal control of plasma membrane -endoplasmic reticulum membrane contacts regulates neuronal excitabilityR35GM149211 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eamonn James Dickson · 2023 to 2026
$1.5MCardiac Regenerative Therapy Using Gene-Edited Stem Cells to Improve Transplantation OutcomesR56HL167932 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SIRISH, PADMINI · 2023 to 2023
$400kBLRD VA I01 BX000576CSRD VA I01 CX001490NHLBI NIH HHS F31 HL165815NHLBI NIH HHS F32 HL149288NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS R01 HL152055NHLBI NIH HHS R01 HL159304NHLBI NIH HHS R56 HL167932NHLBI NIH HHS T32 HL007936NHLBI NIH HHS T32 HL086350NIA NIH HHS R01 AG063796NIGMS NIH HHS R35 GM149211NIGMS NIH HHS T32 GM099608NIH HHS S10 OD010389NINDS NIH HHS RF1 NS131379
Abstract
Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenates cardiac function and substantially reverses the aging phenotype. Our data indicate that age-associated overexpression of BIN1 occurs alongside dysregulated endosomal recycling and disrupted trafficking of cardiac Ca
Indexed as
Adaptor Proteins, Signal TransducingAgingMyocardiumNerve Tissue ProteinsRyanodine Receptor Calcium Release ChannelTumor Suppressor ProteinsAnimalsCalcium Channels, L-TypeEndosomesGene Knockdown TechniquesHeartHumansMaleMiceMice, Inbred C57BLMyocytes, CardiacAdaptor Proteins, Signal TransducingBin1 protein, mouseCalcium Channels, L-TypeNerve Tissue ProteinsNuclear ProteinsRNA, Small InterferingRyanodine Receptor Calcium Release ChannelTumor Suppressor Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.