ArticleNature communications2024
Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Developmental and cellular vulnerabilities underlie genetic architecture of schizophrenia.Molecular psychiatry · 2026Article
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- An adaptive and flexible role for primary sensory cortex.Nature neuroscience · 2026Review
- The Somatosensory Mismatch Negativity.The European journal of neuroscience · 2025Review
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Deviance detection via competitive inhibition between local neocortical ensembles.bioRxiv : the preprint server for biology · 2025Article
- Prioritized learning of cross-population neural dynamics.Journal of neural engineering · 2025Article
- Corticothalamic modulation of somatosensory thalamic tactile processing.The Journal of physiology · 2025Article
- Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental context influences visual processing in thalamus.Current biology : CB · 2025Article
- MULTIPLE DISTINCT TIMESCALES OF RAPID SENSORY ADAPATION IN THE THALAMOCORTICAL CIRCUIT.bioRxiv : the preprint server for biology · 2024Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
The feedback projections from cortical layer 6 (L6CT) to the sensory thalamus have long been implicated in playing a primary role in gating sensory signaling but remain poorly understood. To causally elucidate the full range of effects of these projections, we targeted silicon probe recordings to the whisker thalamocortical circuit of awake mice selectively expressing Channelrhodopsin-2 in L6CT neurons. Through optogenetic manipulation of L6CT neurons, multi-site electrophysiological recordings, and modeling of L6CT circuitry, we establish L6CT neurons as dynamic modulators of ongoing spiking in the ventral posteromedial nucleus of the thalamus (VPm), either suppressing or enhancing VPm spiking depending on L6CT neurons' firing rate and synchrony. Differential effects across the cortical excitatory and inhibitory sub-populations point to an overall influence of L6CT feedback on cortical excitability that could have profound implications for regulating sensory signaling across a range of ethologically relevant conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.