Evidence map›Paper›PMID 38664336›Full record

ArticleEndocrine2024

Clinical and radiographic characteristics of patients with non-functioning pituitary adenomas categorized according to their serum prolactin concentration: novel predictors of postoperative transient diabetes insipidus following surgery.

Kiyohiko Sakata, Aya Hashimoto, Nobuyuki Takeshige, Kimihiko Orito, Ayako Nagayama, Kenji Ashida, Masatoshi Nomura, Motohiro Morioka

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Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kiyohiko SakataDepartment of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan. kiyo@med.kurume-u.ac.jp.
Aya HashimotoDepartment of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan.
Nobuyuki TakeshigeDepartment of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan.ORCID 0000-0001-5343-1574
Kimihiko OritoDepartment of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan.
Ayako NagayamaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Kenji AshidaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.ORCID 0000-0001-8753-6016
Masatoshi NomuraDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.ORCID 0000-0002-0725-3161
Motohiro MoriokaDepartment of Neurosurgery, Kurume University School of Medicine, Fukuoka, Japan.ORCID 0000-0001-7179-1258
Kurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNon-functioning pituitary adenomas (NFPAs) are often associated with hyperprolactinemia, which is known as the "stalk effect". However, the relationships between hyperprolactinemia and the radiographic characteristics of the tumor that affects the pituitary stalk have not been well characterized. We aimed to identify the differences in the clinical and radiographic characteristics of patients with NFPA, with and without hyperprolactinemia.

methodsWe enrolled 107 patients with NFPA and allocated them to hyperprolactinemia and non-hyperprolactinemia groups using two different cut-off values: (1) the upper limit of the normal reference range, adjusted for sex and menopausal status, and (2) the upper quartile across the cohort, and compared their clinical and radiographic characteristics. These analyses were conducted to clarify the relationship between the "stalk effect" and the postoperative change in antidiuretic hormone secretion.

resultsThe specific radiographic characteristics of the patients included the presence of a cystic or hemorrhagic tumor and the presence of pituitary stalk deviation, which were more frequent in the patients with hyperprolactinemia. Interestingly, the incidence of postoperative transient diabetes insipidus was statistically significantly higher in the hyperprolactinemia group (≥40 ng/mL) and in the group with radiologic evidence of stalk deviation, which were shown to be independent risk factors on multivariate analysis.

conclusionThe presence of a "stalk effect" was associated with a higher risk of postoperative transient diabetes insipidus, reflecting perioperative pituitary stalk dysfunction following NFPA surgery, especially in patients with serum prolactin concentrations ≥40 ng/mL and radiologic evidence of stalk deviation.

Indexed as

AdenomaHyperprolactinemiaPituitary NeoplasmsPostoperative ComplicationsProlactinAdolescentAdultAgedAged, 80 and overDiabetes InsipidusFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesProlactinDiabetes insipidusHyperprolactinemiaNon-functioning pituitary adenomaPituitary stalkProlactinomaStalk effect

Identifiers

PMID38664336
OpenAlexW4395446415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.