ArticleBioprocess and biosystems engineering2024
Morphological-metabolic analysis in Streptomyces rimosus microparticle-enhanced cultivations (MPEC).
Article in Bioprocess and biosystems engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Influence of Cellulose Particles on Streptomyces spp. Growth, Morphology, and Metabolite Spectrum.Microbial biotechnology · 2026Article
- Effects of bioreactor inoculation method on secondary metabolite production and morphological characteristics of Streptomyces rimosus in microparticle-enhanced cultivation (MPEC).Microbial cell factories · 2025Article
- Engineering bacterial cell morphology for the design of robust cell factories.Biochemistry and biophysics reports · 2025Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Streptomyces produce a broad spectrum of biologically active molecules such as oxytetracycline and rimocidin, which are widely used in human and animal treatments. microparticle-enhanced cultivation (MPEC) is one of the tools used for Streptomyces bioprocesses intensification by the control of mycelial morphology. In the present work, morphological changes of Streptomyces rimosus caused by the addition of 10 µm talc microparticles in MPEC were correlated with the biosynthetic activity of the microorganism. Comparing the runs with and without microparticles, major morphological changes were observed in MPEC, including the deformation of pellets, variation of their size, appearance of hyphae and clumps as well as the aggregation of mycelial objects. The presence of talc microparticles also influenced the levels of the studied secondary metabolites produced by S. rimosus. Comparing control and MPEC runs, the addition of talc microparticles increased the amounts of oxytetracycline (9-fold), 2-acetyl-2-decarboxamido-oxytetracycline (7-fold), milbemycin A
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