Evidence map›Paper›PMID 38664237›Full record

ArticleJournal of the American Heart Association2024

Long-Term Safety and Efficacy of Transcatheter Microwave and Radiofrequency Denervation in a Chronic Ovine Model.

Poornima Balaji, Michael A Barry, Vu Toan Tran, Simone Marschner, Juntang Lu, Duc Minh Nguyen, Ashraf Mina, Sushil Bandodkar, Shirley Alvarez, Virginia James and 7 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Poornima BalajiCardiology Department Westmead Hospital Sydney NSW Australia.ORCID 0000-0002-8579-1862
Michael A BarryCardiology Department Westmead Hospital Sydney NSW Australia.ORCID 0000-0002-6061-2784
Vu Toan TranCardiology Department Westmead Hospital Sydney NSW Australia.ORCID 0000-0003-1663-1168
Simone MarschnerWestmead Applied Research Centre University of Sydney NSW Australia.ORCID 0000-0002-5484-9144
Juntang LuCardiology Department Westmead Hospital Sydney NSW Australia.ORCID 0000-0002-7438-310X
Duc Minh NguyenCardiology Department Westmead Hospital Sydney NSW Australia.
Ashraf MinaNSW Health Pathology Institute of Clinical Pathology and Medical Research, Westmead Hospital Sydney NSW Australia.ORCID 0000-0002-9252-2062
Sushil BandodkarBiochemistry Department, Faculty of Medicine and Health University of Sydney Children's Hospital at Westmead Clinical School Sydney NSW Australia.ORCID 0000-0001-5000-4518
Shirley AlvarezBiochemistry Department, Faculty of Medicine and Health University of Sydney Children's Hospital at Westmead Clinical School Sydney NSW Australia.ORCID 0009-0004-0507-820X
Virginia JamesThe Westmead Institute of Medical Research Sydney NSW Australia.
John RonquilloDepartment of Anatomical Pathology Institute of Clinical Pathology and Medical Research, Westmead Hospital Sydney NSW Australia.
Winny VarikattDepartment of Anatomical Pathology Institute of Clinical Pathology and Medical Research, Westmead Hospital Sydney NSW Australia.
Pramesh KovoorCardiology Department Westmead Hospital Sydney NSW Australia.
Alistair McEwanWestmead Applied Research Centre University of Sydney NSW Australia.
Aravinda ThiagalingamCardiology Department Westmead Hospital Sydney NSW Australia.
Stuart P ThomasCardiology Department Westmead Hospital Sydney NSW Australia.
Pierre C QianCardiology Department Westmead Hospital Sydney NSW Australia.
The University of Sydney · AUWestmead Hospital · AUNew South Wales Department of Health · AUWestmead Institute for Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter renal denervation (RDN) has had inconsistent efficacy and concerns for durability of denervation. We aimed to investigate long-term safety and efficacy of transcatheter microwave RDN in vivo in normotensive sheep in comparison to conventional radiofrequency ablation. METHODS AND

resultsSheep underwent bilateral RDN, receiving 1 to 2 microwave ablations (maximum power of 80-120 W for 240 s-480 s) and 12 to 16 radiofrequency ablations (180 s-240 s) in the main renal artery in a paired fashion, alternating the side of treatment, euthanized at 2 weeks (acute N=15) or 5.5 months (chronic N=15), and compared with undenervated controls (N=4). Microwave RDN produced substantial circumferential perivascular injury compared with radiofrequency at both 2 weeks [area 239.8 (interquartile range [IQR] 152.0-343.4) mm

conclusionsTranscatheter microwave RDN produces deep circumferential perivascular ablations without significant arterial injury to provide effective and durable RDN at 5.5 months compared with radiofrequency RDN.

Indexed as

KidneyMicrowavesRenal ArterySympathectomyAnimalsBlood PressureCatheter AblationDisease Models, AnimalFemaleRadiofrequency AblationSheepTime Factorsblood pressuremicrowaveradiofrequencyrenal denervation

Identifiers

PMID38664237
PMCPMC11179908
OpenAlexW4395670591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.