Evidence map›Paper›PMID 38664141›Full record

ReviewTrends in biotechnology2024

Physical-property-based patterning: simply engineering complex tissues.

Hannah M Zlotnick, Molly M Stevens, Robert L Mauck

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hannah M ZlotnickBioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
Molly M StevensDepartment of Materials, Department of Bioengineering, and Institute for Biomedical Engineering, Imperial College London, London, UK; Department of Physiology, Anatomy and Genetics, Department of Engineering Science, and Kavli Institute for Nanoscience Discovery, University of Oxford, UK.
Robert L MauckMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Translational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, PA, USA. Electronic address: lemauck@pennmedicine.upenn.edu.

Funding

Dynamic Fibrous Scaffolds for Repairing Dense Connective TissuesR01AR056624 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Jason A Burdick, Robert L Mauck · 2009 to 2026
$7.5M
Engineered Developmental Microenvironments: Cartilage Formation and MaturationR01AR077362 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BURDICK, JASON A, MAUCK, ROBERT L · 2020 to 2024
$2.5M
RR&D Senior Research Career Scientist AwardIK6RX003416 · VA · PHILADELPHIA VA MEDICAL CENTER · PI Robert L Mauck · 2020 to 2026
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Medical Research Council MR/R015651/1NIAMS NIH HHS R01 AR056624NIAMS NIH HHS R01 AR077362RRD VA IK6 RX003416
6 · The paper itself

Abstract

The field of biofabrication is rapidly expanding with the advent of new technologies and material systems to engineer complex tissues. In this opinion article, we introduce an emerging tissue patterning method, physical-property-based patterning, that has strong translational potential given its simplicity and limited dependence on external hardware. Physical-property-based patterning relies solely on the intrinsic density, magnetic susceptibility, or compressibility of an object, its surrounding solution, and the noncontact application of a remote field. We discuss how physical properties can be exploited to pattern objects and design a variety of biologic tissues. Finally, we pose several open questions that, if addressed, could transform the status quo of biofabrication, pushing us one step closer to patterning tissues in situ.

Indexed as

Tissue EngineeringAnimalsHumanscompressibilitydensitymagnetic susceptibilityphysical-property-based patterningremote fieldstissue engineering

Identifiers

PMID38664141
PMCPMC11449661

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.