Evidence map›Paper›PMID 38664109›Full record

ReviewTrends in neurosciences2024

Origin, identity, and function of terminal Schwann cells.

Robert Louis Hastings, Gregorio Valdez

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Gene therapy ameliorates neuromuscular pathology in CLN3 disease.Acta neuropathologica communications · 2025
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. The Human Mechanosensory Corpuscles: A New Schwann Cell Localization of the Wilms' Tumor Protein WT1.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert Louis HastingsDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Gregorio ValdezDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA; Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, and Center on the Biology of Aging, Brown University, Providence, RI, USA. Electronic address: gregorio_valdez@brown.edu.

Funding

Predoctoral Training in the Molecular Biology of AgingT32AG041688 · NIA · BROWN UNIVERSITY · PI NICOLA NERETTI, John M Sedivy · 2012 to 2026
$3.5M
Targeting the fibroblast growth factor binding protein-1 to slow degeneration of neuromuscular junctionsR01AG055545 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2021
$2.2M
Analysis of Sensory Neurons to Understand and Identify Factors to Treat ALSR21NS106313 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2018 to 2019
$433k
Synaptic FGFs are required and sufficient to maintain and repair aged NMJsR56AG051501 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2015 to 2015
$377k
Role of synaptic Schwann cells in NMJ and skeletal muscle agingR56AG077814 · NIA · BROWN UNIVERSITY · PI VALDEZ, GREGORIO · 2022 to 2022
$327k
NIA NIH HHS R01 AG055545NIA NIH HHS R56 AG051501NIA NIH HHS R56 AG077814NIA NIH HHS T32 AG041688NINDS NIH HHS R21 NS106313
6 · The paper itself

Abstract

The highly specialized nonmyelinating glial cells present at somatic peripheral nerve endings, known collectively as terminal Schwann cells (TSCs), play critical roles in the development, function and repair of their motor and sensory axon terminals and innervating tissue. Over the past decades, research efforts across various vertebrate species have revealed that while TSCs are a diverse group of cells, they share a number of features among them. In this review, we summarize the state-of-knowledge about each TSC type and explore the opportunities that TSCs provide to treat conditions that afflict peripheral axon terminals.

Indexed as

Schwann CellsAnimalsHumansamyotrophic lateral sclerosisgliamuscleskinspinal muscular atrophysynaptic function

Identifiers

PMID38664109
PMCPMC11168889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.